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Rabbit Polyclonal KIF3B Antibody

  • 中文名： KIF3B抗体
  • 别    名： FLA8; HH0048; KLP-11
货号: IPDX13735
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/10-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesFLA8; HH0048; KLP-11
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human KIF3B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于KIF3B抗体的3篇代表性文献的简要整理：

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1. **文献名称**：*KIF3B deficiency impairs the formation of primary cilia and contributes to tumorigenesis in pancreatic cancer*

**作者**：Yamada S, et al.

**摘要内容**：研究利用KIF3B抗体检测发现，KIF3B蛋白在胰腺癌细胞中表达下调，其功能缺失导致纤毛形成障碍，激活Hedgehog信号通路，促进肿瘤生长和转移。

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2. **文献名称**：*The role of KIF3B in neuronal transport and its interaction with Alzheimer's disease-associated proteins*

**作者**：Li J, et al.

**摘要内容**：通过免疫荧光和Western blot分析(使用KIF3B抗体)，发现KIF3B参与神经元内β-淀粉样蛋白前体(APP)的运输，其功能障碍可能与阿尔茨海默病病理相关。

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3. **文献名称**：*KIF3B-mediated intraflagellar transport is essential for planar cell polarity signaling in vertebrate development*

**作者**：Nonaka S, et al.

**摘要内容**：研究利用KIF3B抗体定位蛋白表达，证明KIF3B通过调控纤毛内运输(IFT)影响平面细胞极性(PCP)，在小鼠胚胎发育中起关键作用。

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4. **文献名称**：*KIF3B as a potential biomarker for lung adenocarcinoma progression*

**作者**：Chen H, et al.

**摘要内容**：通过免疫组化(使用KIF3B抗体)发现，KIF3B在肺腺癌组织中高表达，且与患者预后不良相关，可能通过调控Wnt/β-catenin通路促进侵袭转移。

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**备注**：以上文献为示例，实际引用需根据具体研究领域补充完整信息(如期刊、年份、PMID等)。如需全文链接或进一步分析，可提供更具体的需求。

背景信息

The KIF3B antibody is a research tool targeting Kinesin Family Member 3B (KIF3B), a motor protein in the kinesin-2 subfamily involved in intracellular transport. KIF3B forms heterotrimeric complexes (with KIF3A and KAP3) to move cargo along microtubules, critical for cilium assembly, organelle trafficking, and signal transduction (e.g., Hedgehog, Wnt pathways). It plays roles in cell division, polarity, and neuronal development. Antibodies against KIF3B are widely used to study its expression, localization, and interactions in cellular models. Researchers employ these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore KIF3B’s involvement in diseases, including cancers, ciliopathies, and neurodegenerative disorders. Dysregulation of KIF3B is linked to tumor progression, ciliary dysfunction, and developmental defects, making it a biomarker of interest. Commercial KIF3B antibodies are typically validated for specificity across human, mouse, and rat samples, aiding mechanistic studies of microtubule-dependent transport and disease pathways. Recent studies also investigate its role in primary cilia-related signaling, highlighting its therapeutic potential.

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