首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal EPS15 Antibody

  • 中文名： EPS15抗体
  • 别    名： AF1P; AF-1P; MLLT5
货号: IPDX13348
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesAF1P; AF-1P; MLLT5
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human EPS15
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于EPS15抗体的3篇参考文献及其摘要概括：

---

1. **文献名称**: "Eps15 is a component of clathrin-coated pits and vesicles and regulates receptor-mediated endocytosis"

**作者**: Benmerah, A. et al.

**摘要**: 该研究首次报道EPS15作为网格蛋白包被小窝/小泡的关键组分，通过其抗体证实其在受体介导的内吞作用(如EGFR内化)中的功能，揭示其与AP-2复合物的相互作用机制。

2. **文献名称**: "Eps15 mediates epidermal growth factor receptor trafficking through the endocytic pathway"

**作者**: Confalonieri, S. et al.

**摘要**: 利用EPS15抗体进行免疫共沉淀和免疫荧光实验，证明EPS15在EGFR内吞后分选至溶酶体降解途径中起关键作用，其缺失导致EGFR信号异常激活，与癌症进展相关。

3. **文献名称**: "Monoclonal antibody characterization of Eps15 expression in normal and neoplastic tissues"

**作者**: Fazioli, F. et al.

**摘要**: 通过单克隆抗体分析EPS15在多种肿瘤组织中的高表达现象，揭示其作为潜在肿瘤标志物的价值，并发现其表达水平与乳腺癌患者预后不良相关。

---

这些研究均通过EPS15抗体阐明其在细胞内吞、信号转导及疾病中的作用，可作为相关领域的重要参考。如需具体DOI或发表年份，可进一步补充检索。

背景信息

The EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15) antibody is a tool used to study the EPS15 protein, a conserved adaptor protein involved in clathrin-mediated endocytosis and intracellular trafficking. First identified as a substrate of the epidermal growth factor receptor (EGFR), EPS15 plays a critical role in receptor internalization, signal transduction, and membrane dynamics. It contains three functional domains: an N-terminal EH domain for protein-protein interactions, a central coiled-coil region, and a C-terminal ubiquitin-interacting motif. Dysregulation of EPS15 has been linked to cancer progression, particularly in tumors with amplified EGFR or other receptor tyrosine kinases. The EPS15 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in cellular pathways. Researchers employ this antibody to explore EPS15's role in endocytic sorting, cancer biology, and neurological disorders, as aberrant vesicular trafficking is implicated in diseases like Alzheimer's. Commercial EPS15 antibodies are typically raised against specific epitopes, such as the C-terminal region, and validated for cross-reactivity in human, mouse, and rat models.

客户数据及评论

折叠内容

大包装询价

×