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Rabbit Polyclonal HLA-A Antibody

  • 中文名： HLA-A抗体
  • 别    名： HLAA
货号: IPDX13345
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesHLAA
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HLA-A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于HLA-A抗体的3篇参考文献(标题、作者和摘要概括)：

1. **"HLA antibody detection and clinical relevance in solid organ transplantation"**

- **作者**: Tait BD, et al.

- **摘要**: 该文献综述了HLA抗体(包括HLA-A亚型)的检测技术(如单抗原微珠法)，及其在肾移植和心脏移植中的临床意义，强调抗体介导的排斥反应风险及术前交叉配型的重要性。

2. **"Clinical impact of HLA-A antibodies in sensitized patients awaiting kidney transplantation"**

- **作者**: Claas FHJ, et al.

- **摘要**: 研究HLA-A特异性抗体对致敏患者肾移植预后的影响，发现高滴度HLA-A抗体会显著增加移植物失功风险，并提出通过脱敏治疗降低抗体水平的策略。

3. **"Mechanisms of HLA-A antibody-mediated endothelial cell injury in transplant rejection"**

- **作者**: Michaels PJ, et al.

- **摘要**: 通过体外实验揭示HLA-A抗体通过激活补体途径和促进内皮细胞炎症因子释放，导致移植物血管损伤的分子机制，为靶向治疗提供依据。

4. **"Advances in HLA antibody testing: Focus on HLA-A and -B epitope analysis"**

- **作者**: Pei R, et al.

- **摘要**: 探讨基于表位水平的HLA-A/B抗体分析技术，通过高通量分型优化供者选择，减少因HLA-A错配导致的移植后并发症。

以上文献涵盖HLA-A抗体的检测技术、临床影响及机制研究，适用于移植免疫学领域参考。

背景信息

HLA-A antibodies are immunoglobulins targeting HLA-A antigens, a subclass of human leukocyte antigen (HLA) class I molecules. HLA-A antigens are critical in adaptive immunity, presenting peptide fragments to CD8+ T-cells for immune surveillance. HLA genes, located on chromosome 6. exhibit extreme polymorphism, with HLA-A alone comprising over 4.000 alleles. Antibodies against HLA-A typically arise after exposure to non-self HLA antigens through events like pregnancy, blood transfusion, or organ transplantation. These antibodies are clinically significant in transplant medicine, as preformed or *de novo* HLA-A antibodies can trigger hyperacute or antibody-mediated rejection in organ transplants, particularly kidneys. They also contribute to platelet transfusion refractoriness and fetal-neonatal alloimmune disorders. Detection methods include solid-phase assays (e.g., Luminex-based single-antigen beads) and complement-dependent cytotoxicity testing. HLA antibody screening and crossmatching are standard in transplant protocols to assess donor-recipient compatibility. Managing HLA-A sensitization may involve desensitization therapies, donor selection strategies, or immunomodulatory agents. Their high specificity and pathogenic potential make HLA-A antibodies a key focus in precision transplantation and hematopoietic cell therapy research.

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