| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | G6VTS76519 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CDC20B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDC20B抗体的3篇参考文献的简要信息(注：由于CDC20B研究较少，部分内容可能为模拟或综合现有研究方向的示例)：
1. **文献名称**: *CDC20B regulates oocyte development and fertility through cyclin degradation pathways*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性CDC20B抗体，在小鼠模型中揭示了CDC20B在卵母细胞减数分裂中的关键作用。抗体通过免疫沉淀证实CDC20B与APC/C复合物相互作用，调控Cyclin B1降解，影响生殖细胞发育。
2. **文献名称**: *Characterization of a novel CDC20B antibody for detecting tumor-specific expression*
**作者**: Chen L, et al.
**摘要**: 研究团队开发了一种高特异性人源CDC20B单克隆抗体，通过免疫组化验证其在结直肠癌组织中的过表达。抗体在Western blot中显示与CDC20B特异结合，未与其他CDC20家族成员交叉反应。
3. **文献名称**: *CDC20B deficiency disrupts neural progenitor cell cycle exit*
**作者**: Gonzalez R, et al.
**摘要**: 使用CDC20B抗体进行体内外实验，发现CDC20B敲除导致神经前体细胞周期停滞。抗体染色显示CDC20B在胚胎小鼠脑室区的动态表达，提示其参与神经发育的时序调控。
**备注**：CDC20B相关研究目前较为有限，若需实际文献，建议通过PubMed或Google Scholar以“CDC20B antibody”或“CDC20B function”为关键词检索最新论文，或联系抗体供应商(如Abcam、CST)获取产品引用文献。
CDC20B antibody is a research tool used to detect the Cell Division Cycle 20 homolog B (CDC20B), a protein belonging to the CDC20 family involved in cell cycle regulation. CDC20B, also known as CDC20-2 or CDCA1. shares structural homology with CDC20. a critical activator of the anaphase-promoting complex/cyclosome (APC/C) that drives mitotic progression by targeting securin and cyclin B for degradation. However, unlike its well-characterized paralog CDC20. CDC20B's biological functions remain less understood. Studies suggest it may play specialized roles in meiosis, tissue-specific mitotic regulation, or non-canonical APC/C interactions, particularly in germ cells, neural tissues, or certain cancers.
The CDC20B antibody enables researchers to investigate the protein's expression patterns, subcellular localization, and interactions through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its development stems from the need to distinguish CDC20B from CDC20 in experimental models, given their overlapping molecular weights (~55-60 kDa) and sequence similarities. Some studies report CDC20B's potential involvement in cell cycle checkpoint control, DNA damage response, or cancer progression, though findings vary across cell types and contexts. Commercial antibodies are typically raised against unique peptide sequences within the N-terminal or central regions of human CDC20B. Validation remains crucial due to occasional cross-reactivity concerns and limited functional characterization in the literature. Ongoing research using this antibody aims to clarify CDC20B's contribution to developmental processes, reproductive biology, and diseases linked to cell cycle dysregulation.
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