Rabbit Polyclonal UNC5B Antibody

UNC5B antibody is a research tool targeting the UNC5B receptor, a transmembrane protein belonging to the UNC-5 family of netrin receptors. UNC5B plays a critical role in axon guidance, cell migration, and apoptosis regulation during development. It acts as a dependence receptor, binding to netrin-1 to promote cell survival and repulsion cues. In the absence of netrin-1. UNC5B triggers caspase-mediated apoptosis, making it essential for tissue homeostasis and cancer progression studies. The UNC5B antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression and localization in tissues or cultured cells. Research applications focus on its roles in angiogenesis, neuronal development, and tumor suppression, particularly in colorectal, breast, and lung cancers where UNC5B dysregulation correlates with metastasis and poor prognosis. Recent studies also explore its involvement in vascular and immune disorders. Validated antibodies enable investigations into UNC5B's interaction with downstream effectors like DCC and its modulation of signaling pathways such as MAPK/ERK. Proper controls, including knockout validation, are crucial for specificity. This antibody has become indispensable for decoding UNC5B's dual functions in development and disease pathophysiology.