| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human UGT2B15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UGT2B15抗体的3篇参考文献(基于模拟数据整理，非真实文献)：
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1. **标题**: "Characterization of UGT2B15 Antibody Specificity in Human Liver Microsomes"
**作者**: Smith A, et al.
**摘要**: 该研究验证了UGT2B15抗体在肝脏微粒体中的特异性，通过Western blot和免疫沉淀技术证明其与UGT2B15蛋白的特异性结合，未与其他UGT家族成员发生交叉反应，为代谢研究提供了可靠工具。
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2. **标题**: "UGT2B15 Expression in Prostate Cancer: Role of a Novel Polyclonal Antibody"
**作者**: Lee JH, et al.
**摘要**: 开发了一种新型多克隆抗体用于检测前列腺癌组织中UGT2B15的表达。免疫组化结果显示，UGT2B15在雄激素非依赖性癌细胞中高表达，提示其可能与激素代谢异常相关。
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3. **标题**: "Development of a Monoclonal Antibody for Quantifying UGT2B15 in Human Plasma"
**作者**: Tanaka M, et al.
**摘要**: 报道了一种高灵敏度单克隆抗体的开发，可通过ELISA定量人血浆中的UGT2B15.研究证实该抗体对UGT2B15具有高亲和力，且与血浆中其他蛋白无交叉反应，适用于药代动力学研究。
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注：以上文献为模拟示例，实际引用请通过PubMed或Web of Science等数据库检索真实文献。
The UGT2B15 antibody is a crucial tool for studying the UDP-glucuronosyltransferase 2B15 (UGT2B15) enzyme, a member of the UGT superfamily responsible for phase II drug metabolism. UGT2B15 catalyzes the glucuronidation of endogenous compounds (e.g., steroids, bile acids) and xenobiotics, enhancing their water solubility for excretion. This enzyme is highly expressed in the liver, prostate, breast, and other steroid-sensitive tissues, where it modulates the bioavailability and activity of hormones like androgens and estrogens. Dysregulation of UGT2B15 has been implicated in hormone-dependent cancers (e.g., prostate, breast) and metabolic disorders, making it a target for therapeutic research.
UGT2B15 antibodies are typically raised in rabbits or mice using peptide antigens derived from conserved regions of the human protein. They enable the detection and quantification of UGT2B15 expression via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated antibodies are essential for investigating tissue-specific expression patterns, enzyme localization, and regulatory mechanisms in disease models. Commercial antibodies often undergo specificity testing using knockout cell lines or siRNA knockdown to ensure minimal cross-reactivity with homologous UGT isoforms like UGT2B17.
These antibodies are widely used in pharmacokinetic studies, cancer biology, and toxicology to explore interindividual variability in drug metabolism and hormone homeostasis. Researchers rely on them to elucidate UGT2B15's role in drug resistance, endocrine signaling, and personalized medicine approaches.
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