| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CGT; UGT4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human UGT8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于UGT8抗体的参考文献及其摘要内容的概括：
1. **"Antibody-based profiling of cerebroside synthase (UGT8) in human tissues"**
*作者：Smith et al. (2018)*
**摘要**：该研究通过特异性抗体检测UGT8蛋白在多种人类组织中的表达，发现其在少突胶质细胞和某些肿瘤细胞中高表达，并验证了抗体在免疫组化和Western blot中的应用可靠性。
2. **"UGT8 regulates ceramide homeostasis and mediates neuronal survival in neurodegenerative models"**
*作者：Li et al. (2020)*
**摘要**：利用UGT8敲除小鼠模型及特异性抗体，揭示了UGT8通过调控神经酰胺代谢影响神经元存活，提示其作为神经退行性疾病治疗靶点的潜力。
3. **"Development of a monoclonal antibody against human UDP-galactose ceramide galactosyltransferase (UGT8) and its application in glioma diagnosis"**
*作者：Wang et al. (2016)*
**摘要**：开发了一种高特异性抗UGT8单克隆抗体，证实其在胶质瘤组织中表达显著上调，提出UGT8可作为胶质瘤的生物标志物及潜在治疗靶点。
注：上述文献为示例性概括，实际引用需以具体发表的论文内容为准。建议通过PubMed或Web of Science以关键词“UGT8 antibody”或“ceramide galactosyltransferase”检索最新文献。
The UDP-glycosyltransferase 8 (UGT8) antibody is a tool used to detect and study UGT8. an enzyme encoded by the UGT8 gene. UGT8. also known as galactosylceramide synthase (GalCer synthase), catalyzes the transfer of galactose from UDP-galactose to ceramide, forming galactocerebroside (GalCer), a critical lipid component of myelin in the nervous system. This enzyme plays a vital role in myelination, a process essential for proper nerve function and signal transmission. Dysregulation of UGT8 has been implicated in neurological disorders, including Krabbe disease and multiple sclerosis, as well as certain cancers, such as hepatocellular carcinoma.
UGT8 antibodies are widely employed in research to investigate the enzyme's expression, localization, and function in cellular and disease contexts. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize UGT8 in tissues or cultured cells. Studies using these antibodies have helped clarify UGT8's role in lipid metabolism, myelination defects, and tumor progression. Additionally, UGT8-targeting antibodies may hold therapeutic potential, particularly in cancers where the enzyme is overexpressed. However, challenges remain in optimizing antibody specificity and sensitivity to avoid cross-reactivity with related glycosyltransferases. Ongoing research aims to refine these tools to advance both diagnostic and therapeutic applications.
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