Rabbit Polyclonal HAUS7 Antibody

The HAUS7 antibody targets the HAUS7 protein, a key component of the HAUS complex (homologous to augmin subunits), which plays a critical role in microtubule organization during mitosis. The HAUS complex, composed of eight subunits (HAUS1-8), facilitates the nucleation and branching of microtubules by recruiting γ-tubulin ring complexes (γ-TuRCs) to existing spindle microtubules. This process ensures proper spindle assembly, chromosome segregation, and mitotic fidelity. HAUS7. specifically, stabilizes the HAUS complex and mediates its interaction with other mitotic regulators, such as the Aurora A kinase. Dysregulation of HAUS7 is linked to mitotic defects, genomic instability, and potential associations with cancer or developmental disorders. Antibodies against HAUS7 are widely used in research to study its expression, localization, and function in cell division, often through techniques like immunofluorescence, Western blotting, or co-immunoprecipitation. These tools have helped elucidate HAUS7's role in maintaining microtubule network integrity and its broader implications in diseases linked to mitotic errors. Commercial HAUS7 antibodies are typically validated for specificity across human, mouse, and other model organisms.