| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | THIF; VDUP1; HHCPA78; EST01027 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TXNIP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于TXNIP抗体的代表性文献(示例基于真实研究背景，具体文献需核实数据库)：
1. **文献名称**：*"TXNIP mediates high glucose-induced β-cell apoptosis through regulation of the mitochondrial pathway"*
**作者**：Sato Y et al.
**摘要**：该研究通过Western blot和免疫组化使用TXNIP抗体，证明高葡萄糖环境下胰岛β细胞中TXNIP表达上调，通过激活线粒体凋亡通路诱导细胞死亡。
2. **文献名称**：*"TXNIP suppression protects mice against oxidative stress via Nrf2 pathway activation"*
**作者**：Zhou R et al.
**摘要**：利用TXNIP抗体检测基因敲除小鼠组织样本，发现TXNIP缺失可激活Nrf2抗氧化通路，减轻氧化应激损伤，并抑制NLRP3炎症小体活化。
3. **文献名称**：*"TXNIP antibody-based immunohistochemical analysis in human cancers reveals its prognostic value"*
**作者**：Chen Z et al.
**摘要**：通过TXNIP抗体对多种癌症组织进行免疫组化染色，发现TXNIP低表达与患者生存率降低显著相关，提示其作为肿瘤预后标志物的潜力。
4. **文献名称**：*"TXNIP regulates NLRP3 inflammasome activation in Alzheimer's disease microglia"*
**作者**：Wang L et al.
**摘要**：采用TXNIP抗体检测阿尔茨海默病模型小鼠脑组织，证实TXNIP通过促进NLRP3炎症小体组装加剧神经炎症，抗体特异性验证通过siRNA敲降实验完成。
(注：以上为模拟示例，实际文献需通过PubMed/Web of Science等平台以“TXNIP antibody”为关键词检索获取。)
The thioredoxin-interacting protein (TXNIP), also known as VDUP1 or TBP-2. is a key regulator of cellular redox homeostasis and metabolic pathways. It binds to thioredoxin (Trx), inhibiting its antioxidant activity and promoting oxidative stress. TXNIP is involved in glucose metabolism, insulin sensitivity, and apoptosis, with links to diseases like diabetes, cancer, cardiovascular disorders, and neurodegenerative conditions. Its expression is influenced by glucose levels, hypoxia, and inflammatory signals, often acting as a stress-responsive protein.
TXNIP antibodies are essential tools for detecting and quantifying TXNIP in research. They enable studies on its interaction with Trx, regulatory roles in the NLRP3 inflammasome activation, and contributions to pathological processes. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore tissue-specific expression patterns or disease-associated changes. For example, elevated TXNIP levels in diabetic models highlight its role in β-cell dysfunction, while its suppression in cancers underscores tumor-specific metabolic adaptations.
Research on TXNIP has therapeutic implications, targeting it to modulate oxidative stress or inflammation. Antibodies also aid in validating TXNIP knockdown/overexpression models and screening drug candidates. Understanding TXNIP's dual roles—both protective and detrimental—depends heavily on reliable detection methods, making high-specificity antibodies critical for advancing related biomedical studies.
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