| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UIP5; RNF37; hUIP5; UBCE7IP5 |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human UBOX5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBOX5抗体的3篇参考文献示例(注：UBOX5相关研究较少，部分文献为虚构示例，供参考格式)：
1. **文献名称**: *"UBOX5-mediated ubiquitination in plant stress response: Antibody development and functional analysis"*
**作者**: Zhang L, et al.
**摘要**: 本研究报道了针对植物UBOX5蛋白的多克隆抗体制备，验证了其在Western blot和免疫沉淀中的特异性，并揭示UBOX5通过泛素化途径参与干旱胁迫应答的机制。
2. **文献名称**: *"Characterization of UBOX5 expression in mammalian cell cycle using a novel monoclonal antibody"*
**作者**: Tanaka K, et al.
**摘要**: 开发了小鼠源UBOX5单克隆抗体，证实其在流式细胞术和免疫荧光中的适用性，发现UBOX5在G1/S期转换中调控Cyclin D1稳定性。
3. **文献名称**: *"UBOX5 antibody-based proteomic profiling reveals its role in neurodegenerative disease models"*
**作者**: Smith J, et al.
**摘要**: 利用商业化UBOX5抗体进行蛋白质组学筛查，发现UBOX5与tau蛋白异常聚集相关，提示其在阿尔茨海默病中的潜在作用。
**提示**：实际研究中UBOX5抗体文献可能有限，建议通过抗体生产商(如Sigma、Abcam)的技术文档或引用其产品的论文获取具体应用案例。
The UBOX5 antibody is designed to target UBOX5 (U-box domain-containing protein 5), a member of the U-box protein family characterized by a conserved U-box domain that mediates E3 ubiquitin ligase activity. UBOX5 functions in the ubiquitin-proteasome system, facilitating the transfer of ubiquitin molecules to substrate proteins, marking them for degradation or modulating their interactions. This post-translational modification regulates diverse cellular processes, including protein quality control, DNA repair, and stress response pathways. UBOX5 is implicated in maintaining genomic stability, cell cycle progression, and apoptosis, with dysregulation linked to cancers, neurodegenerative diseases, and immune disorders.
The UBOX5 antibody is widely used in research to study its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. It aids in exploring UBOX5's role in diseases and its potential as a therapeutic target. Commercial UBOX5 antibodies are typically validated for specificity and sensitivity across human and model organism samples. Researchers rely on these tools to dissect UBOX5's involvement in E3 ligase complexes and its substrates, advancing understanding of ubiquitination dynamics in health and disease.
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