| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBE2V2抗体的参考文献示例(注：以下内容为虚构示例，仅用于演示格式)：
1. **"UBE2V2 promotes tumor progression in breast cancer via NF-κB signaling"**
- **作者**: Zhang, Y. et al. (2020)
- **摘要**: 研究通过免疫组化(使用UBE2V2特异性抗体)发现UBE2V2在乳腺癌组织中高表达，并通过激活NF-κB通路促进肿瘤侵袭和转移。
2. **"UBE2V2 as a prognostic biomarker in colorectal cancer"**
- **作者**: Wang, L. et al. (2018)
- **摘要**: 利用UBE2V2抗体进行Western blot和组织芯片分析，揭示UBE2V2高表达与结直肠癌患者不良预后显著相关，提示其作为潜在生物标志物。
3. **"UBE2V2 regulates DNA repair through ubiquitination pathways"**
- **作者**: Smith, J. & Brown, R. (2019)
- **摘要**: 通过UBE2V2抗体敲低实验，证明UBE2V2参与调控DNA损伤修复机制，影响细胞对化疗药物的敏感性。
4. **"UBE2V2 modulates inflammatory responses in macrophages"**
- **作者**: Li, X. et al. (2021)
- **摘要**: 研究采用UBE2V2抗体进行流式细胞术和共聚焦成像，发现UBE2V2通过泛素化修饰TLR4受体，增强巨噬细胞的炎症反应。
(注：若需真实文献，建议通过PubMed或Google Scholar以“UBE2V2 antibody” + “cancer/inflammation”等关键词检索。)
The UBE2V2 antibody is a research tool designed to detect and study the ubiquitin-conjugating enzyme E2 V2 (UBE2V2), a member of the E2 ubiquitin-conjugating enzyme family. UBE2V2. also known as UBE2V1 or CROC-1. plays a role in the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and post-translational modification. Unlike canonical E2 enzymes, UBE2V2 lacks the catalytic cysteine residue required for direct ubiquitin transfer, functioning instead as a non-canonical E2 variant. It typically forms heterodimers with UBE2N (UBE2V2-UBE2N complex) to catalyze Lys63-linked polyubiquitination, a process involved in non-degradative signaling pathways such as DNA repair, NF-κB activation, and inflammatory responses.
UBE2V2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate its expression, localization, and interactions in cellular contexts. Dysregulation of UBE2V2 has been implicated in cancer progression, neurodegenerative diseases, and immune disorders, making these antibodies valuable for studying disease mechanisms. Researchers also explore UBE2V2's role as a potential biomarker or therapeutic target, particularly in tumors where UPS dysregulation drives pathogenesis. Validated antibodies ensure specificity for distinguishing UBE2V2 from homologous proteins, aiding functional studies and translational research.
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