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Rabbit Polyclonal XAB2 Antibody

  • 中文名: XAB2抗体
  • 别    名: HCNP; HCRN; SYF1; NTC90
货号: IPDX05985
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于XAB2抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: "XAB2. a Novel Tetratricopeptide Repeat Protein Involved in Transcription-coupled DNA Repair and Transcription"

**作者**: Y. Nakatsu et al.

**摘要**: 该研究鉴定了XAB2作为转录偶联核苷酸切除修复(TC-NER)的关键因子,发现其通过RNA聚合酶II相互作用参与DNA损伤修复。研究利用XAB2抗体进行免疫沉淀和免疫荧光,证实XAB2与CSA、CSB等修复蛋白复合体结合,并调控转录与修复的协同作用。

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2. **文献名称**: "Involvement of XAB2 in the Coordination of Transcription, Processing, and Export of mRNAs"

**作者**: I. Kuraoka et al.

**摘要**: 本文揭示了XAB2在mRNA代谢中的多功能性,通过XAB2抗体检测其在细胞核内的定位。实验表明,XAB2与剪接体组分(如PRP19)及mRNA输出因子相互作用,协调转录后加工和损伤应答,提示其在连接DNA修复与RNA代谢中的桥梁作用。

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3. **文献名称**: "Functional Analysis of XAB2 Using siRNA and Antibody-based Knockdown in Human Cells"

**作者**: S. Fazio et al.

**摘要**: 研究通过siRNA和XAB2抗体介导的蛋白敲低,分析XAB2缺失对细胞的影响。结果显示,XAB2缺失导致DNA损伤敏感性增加、转录阻滞及RNA剪接异常,进一步支持其作为多功能复合物核心因子的角色。

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**备注**:以上文献为示例,实际文献需通过PubMed或Google Scholar检索关键词如“XAB2 antibody”、“XAB2 function”获取。建议结合最新研究(2020年后)以补充前沿进展。

背景信息

The XAB2 (XPA-binding protein 2) antibody is a tool used to study the multifunctional protein XAB2. which plays critical roles in transcription-coupled DNA repair (TCR), pre-mRNA splicing, and transcription regulation. XAB2. also known as SYF1 or HCNP, is part of the spliceosome-associated SYF complex and interacts with RNA polymerase II (RNAPII), facilitating coordination between transcription and DNA repair. It contains conserved domains, including TPR repeats, which mediate protein-protein interactions. In TCR, XAB2 helps recruit nucleotide excision repair (NER) factors, such as XPA, to sites of DNA damage stalled during transcription. XAB2 antibodies are essential for detecting its expression, localization, and interactions in studies exploring genome stability, transcription-coupled repair mechanisms, and spliceosome dynamics. Dysregulation of XAB2 is linked to developmental defects and diseases like cancer, making its antibody valuable for both basic research and clinical investigations. These antibodies are used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to dissect XAB2's roles in cellular pathways and disease contexts.

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