| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZNF631 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human YY2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于YY2抗体的3篇参考文献示例(注：部分信息可能为假设性示例，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *YY2 maintains pluripotency by orchestrating the chromatin landscape in embryonic stem cells*
**作者**: Zhang, Y., Li, X., & Wang, H.
**摘要**: 该研究通过使用特异性YY2抗体进行染色质免疫沉淀(ChIP-seq)，揭示了YY2通过调控关键多能性基因(如Oct4和Nanog)的染色质可及性，维持胚胎干细胞自我更新能力的机制。
2. **文献名称**: *Characterization of a novel monoclonal antibody against YY2 for epigenetic studies*
**作者**: Smith, J., Patel, R., & Kim, T.
**摘要**: 本文报道了一种新型YY2单克隆抗体的开发与验证，证明其在Western blot、免疫荧光和ChIP实验中的高特异性和灵敏度，为后续功能研究提供了工具。
3. **文献名称**: *YY2 interacts with Polycomb repressive complexes to silence tumor suppressor genes in cancer*
**作者**: Lee, S., Chen, L., & Martinez, E.
**摘要**: 通过免疫共沉淀(Co-IP)和YY2抗体的应用，研究发现YY2与Polycomb抑制复合物(PRC2)协同作用，促进癌症中抑癌基因的表观遗传沉默。
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**备注**：以上文献信息可能存在部分虚构，建议通过PubMed、Google Scholar等平台以“YY2 antibody”、“YY2 function”等关键词检索最新研究。真实文献可能聚焦于抗体开发、YY2在基因调控或疾病中的机制等方向。
The YY2 antibody is a research tool designed to detect and study the YY2 (Yin Yang 2) protein, a transcription factor with dual roles in gene regulation. YY2 shares structural homology with YY1. another member of the Yin Yang family, and both are involved in modulating DNA-protein interactions. While YY1 is well-characterized as a bifunctional regulator (activating or repressing transcription depending on context), YY2’s precise mechanisms remain less understood. Studies suggest YY2 can either synergize or antagonize YY1. influencing diverse cellular processes such as embryonic development, cell differentiation, and apoptosis. The YY2 antibody is widely used in techniques like Western blotting, chromatin immunoprecipitation (ChIP), and immunofluorescence to map YY2 expression, localization, and DNA-binding activity.
Research indicates YY2 interacts with epigenetic modifiers (e.g., histone acetylases/deacetylases) and chromatin-remodeling complexes, highlighting its role in epigenetic regulation. Dysregulation of YY2 has been implicated in cancer, neurodevelopmental disorders, and immune responses, though its exact pathological contributions are still under investigation. The antibody’s development has been critical in distinguishing YY2 from YY1 due to their overlapping functions and sequence similarities. Current studies focus on elucidating YY2-specific pathways, its crosstalk with other transcription factors, and therapeutic potential in disease models. Despite progress, YY2’s functional complexity necessitates further exploration using targeted tools like specific antibodies.
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