| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TMPRSS1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HPN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBTF抗体的示例参考文献，格式为文献名称、作者及简要摘要：
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1. **"UBTF regulates nucleolar localization and phase separation of rRNA transcription machinery"**
*Smith J, et al. (2020)*
摘要：研究通过UBTF抗体进行免疫荧光染色，揭示UBTF在核仁中的动态定位及其通过相分离机制调控rRNA转录的分子机制。
2. **"Development and validation of a polyclonal antibody against human UBTF for chromatin immunoprecipitation (ChIP)"**
*Chen L, et al. (2018)*
摘要：报道了一种特异性识别UBTF的多克隆抗体的开发，验证了其在ChIP实验中的有效性，证实UBTF与rRNA基因启动子的结合。
3. **"Aberrant UBTF expression in glioblastoma correlates with tumor progression"**
*Wang Y, et al. (2021)*
摘要：利用UBTF抗体进行Western blot和免疫组化分析，发现胶质母细胞瘤中UBTF表达异常上调，并与患者预后不良相关。
4. **"UBTF variants in neurodegenerative disorders: Insights from antibody-based proteomic profiling"**
*Garcia R, et al. (2019)*
摘要：通过UBTF抗体检测患者脑组织样本，发现UBTF蛋白异常聚集与阿尔茨海默病的病理进展存在潜在关联。
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**说明**：以上文献为示例，实际引用时请通过PubMed、Google Scholar等平台检索最新研究，关键词可组合“UBTF antibody”、“UBTF function”、“rRNA transcription”等。
UBTF (Upstream Binding Transcription Factor), also known as UBF, is a critical regulatory protein involved in ribosomal RNA (rRNA) transcription by RNA polymerase I. It belongs to the high-mobility group (HMG)-box protein family and binds to the upstream control element of ribosomal DNA (rDNA) promoters, facilitating the assembly of the transcription pre-initiation complex. UBTF plays a dual role: it stabilizes chromatin architecture and recruits essential factors like SL1/TIF-IB to promote rDNA transcription, a key process in ribosome biogenesis essential for cell growth and proliferation.
Antibodies targeting UBTF are widely used in research to investigate its expression, localization, and functional interactions. These antibodies enable detection of UBTF in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Studies leveraging UBTF antibodies have revealed its dysregulation in cancers, where hyperactive rRNA synthesis drives tumor progression, and in neurodegenerative disorders linked to nucleolar stress. Additionally, UBTF mutations are associated with pediatric neuroregression syndromes, highlighting its role in cellular homeostasis.
Available as monoclonal or polyclonal variants, UBTF antibodies often target conserved regions like the HMG-box domains or specific isoforms (e.g., UBF1/UBF2). Researchers prioritize antibodies validated for species cross-reactivity (human, mouse, rat) and application-specific efficacy. Understanding UBTF dynamics through these tools continues to advance insights into ribosomopathies, cancer mechanisms, and therapeutic targeting of Pol I transcription.
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