Rabbit Polyclonal GRWD1 Antibody

The GRWD1 (Glioma-related WD repeat domain-containing protein 1) antibody is a research tool used to study the role of GRWD1. a protein implicated in chromatin regulation and ribosome biogenesis. GRWD1 contains WD40 repeats, structural motifs that facilitate protein-protein interactions, and is localized to the nucleolus, where it associates with histone chaperones and ribosomal proteins. It plays a dual role: as a chromatin regulator, it modulates histone H3K4 methylation and interacts with the tumor suppressor p53. potentially influencing its stability and activity. In ribosome biogenesis, GRWD1 aids in ribosomal RNA (rRNA) processing and ribosome assembly. Overexpression of GRWD1 has been linked to poor prognosis in cancers like colorectal and ovarian cancer, possibly by promoting cell proliferation and genomic instability. Researchers use GRWD1 antibodies in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions with other molecules. These studies aim to clarify its contributions to oncogenesis, ribosome dysfunction, and epigenetic regulation, with potential implications for developing cancer biomarkers or therapeutic targets.