| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACAD2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IVD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条模拟生成的IVD抗体相关参考文献示例(实际文献请通过学术平台查询)：
1. **《Development of high-affinity monoclonal antibodies for SARS-CoV-2 antigen detection》**
- 作者：Smith J, et al. (2021)
- 摘要：本研究报道了一种针对SARS-CoV-2核衣壳蛋白的单克隆抗体的开发，通过噬菌体展示技术筛选出高亲和力抗体对，用于侧向流免疫层析试纸条(LFIA)，临床验证显示灵敏度达98.2%，适用于COVID-19快速诊断。
2. **《CRISPR-Cas12a-mediated signal amplification in lateral flow assays for ultrasensitive cardiac troponin I detection》**
- 作者：Wang L, et al. (2020)
- 摘要：结合CRISPR-Cas12a系统与胶体金标记抗体，开发了超灵敏心肌肌钙蛋白I(cTnI)检测方法，检测限低至0.1 pg/mL，为心血管疾病的早期诊断提供了新策略。
3. **《Multiplexed electrochemical immunosensor for simultaneous detection of cancer biomarkers using graphene oxide-modified electrodes》**
- 作者：Chen X, et al. (2018)
- 摘要：基于氧化石墨烯和三种肿瘤标志物(CEA、AFP、CA125)特异性抗体的电化学免疫传感器，实现了血清样本中多标志物同步检测，在结直肠癌和肝癌诊断中表现出高特异性与可重复性。
4. **《Evaluation of cross-reactivity in commercial IVD autoimmune antibody kits: Challenges and standardization approaches》**
- 作者：Garcia R, et al. (2023)
- 摘要：系统评估了8种市售自身免疫抗体检测试剂盒(抗核抗体/ANAs)的交叉反应性，提出基于表位定位的抗体工程优化方案，推动检测标准化。
**注**：以上为模拟内容，实际文献请通过PubMed、Web of Science或Google Scholar搜索关键词如"IVD antibodies", "diagnostic antibody development", "immunoassay clinical validation"等获取。
In vitro diagnostic (IVD) antibodies are critical components in medical testing, enabling the detection and quantification of specific biomarkers in biological samples. Developed through hybridoma or recombinant technologies, these antibodies are designed to bind with high specificity to targets like proteins, hormones, pathogens, or cellular markers. Their applications span immunoassays (e.g., ELISA, lateral flow tests), clinical chemistry analyzers, and molecular diagnostics, aiding in disease diagnosis, monitoring, and therapeutic guidance.
The IVD antibody market has grown significantly due to rising demand for early disease detection, personalized medicine, and infectious disease surveillance (e.g., COVID-19 rapid tests). Monoclonal antibodies dominate due to consistency and scalability, while polyclonal antibodies remain useful for detecting complex antigens. Recent advancements include recombinant antibodies engineered for enhanced stability and reduced cross-reactivity, improving test accuracy.
Regulatory standards (e.g., FDA, CE-IVD) ensure antibody performance and reproducibility, addressing challenges like batch-to-batch variability. Emerging trends focus on multiplexed assays, point-of-care testing, and AI-driven antibody design. However, high development costs and stringent validation requirements persist as industry hurdles. As precision medicine expands, IVD antibodies will continue to underpin innovations in diagnostics, bridging laboratory research with clinical decision-making.
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