| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LCP; HCLP1; HCLP-1 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KLHDC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KLHDC2抗体的3篇文献示例(内容为模拟概括，具体文献需根据实际检索补充)：
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1. **文献名称**: *KLHDC2 regulates DNA replication and promotes cell cycle progression in cancer cells*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用KLHDC2特异性抗体探究其在肿瘤细胞周期中的作用，发现KLHDC2通过与DNA复制相关蛋白结合促进细胞增殖，抗体免疫组化显示其在多种癌症组织中高表达。
2. **文献名称**: *Characterization of KLHDC2 as a novel biomarker in Alzheimer’s disease*
**作者**: Smith JL, et al.
**摘要**: 通过KLHDC2抗体进行脑组织Western blot和免疫荧光分析，发现KLHDC2在阿尔茨海默病患者神经元中异常聚集，可能与tau蛋白病理相关。
3. **文献名称**: *KLHDC2 antibody-based screening identifies its role in hepatocellular carcinoma metastasis*
**作者**: Wang Q, et al.
**摘要**: 使用KLHDC2抗体筛选肝癌患者样本，发现其高表达与血管浸润和不良预后相关，体内实验表明KLHDC2通过调控EMT通路促进肿瘤转移。
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如需具体文献，建议通过PubMed或Google Scholar以“KLHDC2 antibody”为关键词检索，并筛选实验应用方向(如疾病机制、蛋白互作等)。
The KLHDC2 antibody targets the Kelch domain-containing protein 2 (KLHDC2), a member of the Kelch superfamily characterized by conserved β-propeller Kelch repeat motifs. KLHDC2 is implicated in protein-protein interactions and is thought to act as a substrate receptor for CUL2-based E3 ubiquitin ligase complexes, facilitating substrate recognition and subsequent ubiquitination for proteasomal degradation. While its precise biological roles remain under investigation, KLHDC2 has been linked to cellular processes such as cell cycle regulation, apoptosis, and stress response. Dysregulation of KLHDC2 expression has been observed in certain cancers, suggesting potential involvement in tumorigenesis or tumor suppression, though mechanistic insights are limited.
KLHDC2 antibodies are primarily utilized in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These tools aid in elucidating KLHDC2’s function in physiological and pathological contexts. Commercial antibodies are typically validated for specificity, often through knockout cell lines or siRNA knockdown. Emerging studies explore KLHDC2’s role in diseases beyond cancer, including neurological disorders, highlighting its broader relevance. However, standardized protocols and comprehensive functional data remain scarce, underscoring the need for further characterization. KLHDC2 antibodies thus serve as critical reagents for advancing understanding of its molecular mechanisms and therapeutic potential.
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