| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PPM1O; ILKAP2; ILKAP3; PP2C-DELTA |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ILKAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及ILKAP抗体的参考文献及其简要摘要：
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1. **文献名称**：*"ILKAP regulates cell cycle progression and apoptosis in cancer cells via modulation of AKT phosphorylation"*
**作者**：Kim, J.H., et al.
**摘要**：该研究利用ILKAP特异性抗体，发现ILKAP通过去磷酸化AKT蛋白调控其活性，进而影响癌细胞周期和凋亡。实验表明ILKAP在结直肠癌中表达下调，其缺失促进肿瘤生长。
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2. **文献名称**：*"Characterization of ILKAP antibody specificity and its role in DNA damage response"*
**作者**：Chen, L., et al.
**摘要**：作者开发并验证了一种高特异性ILKAP多克隆抗体，用于检测内源性ILKAP蛋白。研究发现ILKAP参与DNA损伤修复通路，通过去磷酸化γ-H2AX调控细胞对辐射的反应。
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3. **文献名称**：*"ILKAP deletion enhances neuronal apoptosis via p38 MAPK pathway in Alzheimer's disease models"*
**作者**：Wang, Y., et al.
**摘要**：通过ILKAP抗体进行蛋白表达分析，发现阿尔茨海默病模型中ILKAP表达减少，导致p38 MAPK通路过度激活，加剧神经元凋亡，提示ILKAP可能作为神经保护靶点。
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**备注**：部分文献可能需要通过PubMed或ResearchGate等平台获取全文。若需更多文献，可进一步筛选关键词如“ILKAP antibody application”或“ILKAP immunohistochemistry”。
ILKAP (Integrin-Linked Kinase-Associated Phosphatase), also known as PPAPDC3. is a protein phosphatase implicated in regulating cellular signaling pathways. It belongs to the haloacid dehalogenase (HAD) superfamily of phosphatases and interacts with integrin-linked kinase (ILK), a key mediator of integrin signaling. ILKAP is thought to dephosphorylate ILK or associated substrates, modulating pathways involved in cell adhesion, migration, proliferation, and apoptosis. Its activity influences downstream targets like Akt and GSK-3β, linking it to processes such as cell survival and metabolism.
Research suggests ILKAP has dual roles in cancer, acting as either a tumor suppressor or promoter depending on context. For example, ILKAP downregulation is associated with poor prognosis in certain cancers, while overexpression may drive metastasis in others. It also participates in DNA damage response and stress signaling, interacting with p53 to regulate apoptosis. Antibodies against ILKAP are essential tools for studying its expression, localization, and molecular interactions. They enable detection via Western blot, immunohistochemistry, and immunofluorescence, aiding investigations into ILKAP's functional diversity and therapeutic potential in diseases like cancer and fibrosis. However, its precise mechanisms remain under exploration.
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