| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | IMPD2; IMPDH-II |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IMPDH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IMPDH2抗体的参考文献示例(内容基于知识库构造，建议通过PubMed或Google Scholar获取真实文献)：
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1. **标题**：*IMPDH2 overexpression promotes colorectal cancer progression and predicts poor prognosis*
**作者**：Zhang Y, et al.
**摘要**：本研究通过Western blot和免疫组化(使用IMPDH2抗体)检测结直肠癌组织中IMPDH2的表达，发现其高表达与肿瘤侵袭性及患者生存率降低显著相关，提示IMPDH2可能作为潜在的预后标志物。
2. **标题**：*IMPDH2 regulates T cell activation through metabolic reprogramming*
**作者**：Li H, et al.
**摘要**：利用IMPDH2抗体进行流式细胞术和免疫沉淀实验，发现抑制IMPDH2会破坏T细胞内的鸟苷酸代谢，导致活化受阻，为自身免疫疾病治疗提供了新靶点。
3. **标题**：*Structural insights into IMPDH2 regulation by post-translational modifications*
**作者**：Wang X, et al.
**摘要**：通过免疫印迹(IMPDH2抗体)和质谱分析，揭示了磷酸化对IMPDH2酶活性的调控机制，为开发靶向IMPDH2的小分子药物奠定基础。
4. **标题**：*Targeting IMPDH2 in leukemia stem cells enhances chemosensitivity*
**作者**：Chen L, et al.
**摘要**：在白血病干细胞中，IMPDH2抗体用于检测蛋白表达水平，结果显示抑制IMPDH2可增强化疗药物敏感性，提示其作为联合治疗靶点的潜力。
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建议通过学术数据库(如PubMed)以“IMPDH2 antibody”或“IMPDH2 + [研究领域]”为关键词检索最新文献。
IMPDH2 (Inosine-5'-monophosphate dehydrogenase 2) is a key enzyme in the de novo biosynthesis of guanine nucleotides, catalyzing the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP). This rate-limiting step is critical for maintaining cellular GTP and dGTP pools, particularly in rapidly proliferating cells such as activated lymphocytes and cancer cells. IMPDH2. the predominant isoform in most human tissues, has drawn significant attention due to its role in cell cycle progression, metabolic adaptation, and disease pathogenesis.
Antibodies targeting IMPDH2 are widely used in research to investigate its expression patterns, subcellular localization, and functional regulation. Studies have linked IMPDH2 dysregulation to various conditions, including cancer progression, antiviral responses, and autoimmune disorders. Its overexpression in certain tumors has prompted exploration of IMPDH2 as a potential therapeutic target or biomarker. Additionally, IMPDH2 serves as the major target of immunosuppressive drugs like mycophenolic acid, underscoring its relevance in immunology and transplantation research.
IMPDH2 antibodies are commonly employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in disease models or drug-treated cells. Recent research also focuses on its non-catalytic functions, including interactions with cytoskeletal proteins and involvement in nucleotide metabolism-independent pathways. The high conservation of IMPDH2 across species enhances its utility in translational studies using experimental models.
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