WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
Aliases | HSE; RODH; SDR9C6 |
WB Predicted band size | 36 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Fusion protein of human HSD17B6 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSD17B6抗体的3篇代表性文献的简要总结(注:文献信息为模拟示例,非真实存在):
1. **文献名称**: *"HSD17B6 expression in prostate cancer and its role in androgen metabolism"*
**作者**: Smith A, et al.
**摘要**: 该研究利用HSD17B6特异性抗体,通过免疫组化和Western blot技术,发现HSD17B6在前列腺癌组织中高表达,并证实其通过调控双氢睾酮(DHT)的合成促进肿瘤进展。
2. **文献名称**: *"Characterization of HSD17B6 antibody specificity in hepatic steroidogenic pathways"*
**作者**: Chen L, et al.
**摘要**: 文章验证了一种新型HSD17B6单克隆抗体的特异性,证明其在人肝组织中对HSD17B6蛋白的高效检测能力,并揭示该酶在类固醇激素代谢中的关键作用,尤其是与胆汁酸合成的关联。
3. **文献名称**: *"HSD17B6 as a potential biomarker in breast cancer: Insights from antibody-based assays"*
**作者**: Gupta R, et al.
**摘要**: 研究使用HSD17B6抗体进行乳腺癌组织芯片分析,发现HSD17B6表达与雌激素受体阴性亚型相关,提示其可能作为预后标志物及治疗靶点。
4. **文献名称**: *"Functional analysis of HSD17B6 knockout mice using targeted antibody validation"*
**作者**: Tanaka K, et al.
**摘要**: 通过构建HSD17B6基因敲除小鼠模型,结合抗体免疫荧光技术,证明该酶在睾丸和肾上腺中的定位,并揭示其缺失导致雄激素代谢紊乱的表型。
建议通过PubMed或Google Scholar检索真实文献时使用关键词 **"HSD17B6 antibody"** 或 **"HSD17B6 function"** 获取最新研究。
The HSD17B6 antibody is a tool used to detect and study the hydroxysteroid 17-beta dehydrogenase 6 (HSD17B6) enzyme, which belongs to the 17β-hydroxysteroid dehydrogenase (17β-HSD) family. This enzyme plays a role in steroid metabolism, particularly in the conversion of inactive steroid precursors to active forms. HSD17B6 is involved in androgen biosynthesis, catalyzing reactions such as the conversion of androstanediol to dihydrotestosterone (DHT) and participating in retinol metabolism. Its expression is observed in tissues like the liver, prostate, and testes, linking it to hormonal regulation and metabolic pathways.
Researchers utilize HSD17B6 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate the enzyme's localization, expression levels, and role in physiological or pathological processes. Studies focus on its implications in hormone-dependent cancers (e.g., prostate cancer), endocrine disorders, and metabolic diseases. The antibody aids in understanding how HSD17B6 influences steroid hormone balance, cellular proliferation, and disease progression. Additionally, HSD17B6's interaction with lipid metabolism and bile acid synthesis has sparked interest in its broader metabolic functions. Validating antibody specificity is critical to ensure accurate detection, given the structural similarities among 17β-HSD family members. Overall, the HSD17B6 antibody serves as a key reagent in exploring steroid biology and its clinical associations.
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