| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | IKKE; IKKI; IKK-E; IKK-i |
| WB Predicted band size | 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IKBKE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于IKBKE抗体的3篇参考文献，按研究方向和摘要内容分类整理：
---
### 1. **文献名称**：*IKBKE is a therapeutic target in triple-negative breast cancer*
**作者**：Boehm JS et al.
**摘要**：该研究利用特异性IKBKE抗体验证了IKBKE在三阴性乳腺癌细胞中的高表达，并发现其通过激活NF-κB和STAT3信号通路促进肿瘤生长。研究还表明，靶向抑制IKBKE可显著减少肿瘤侵袭性。
---
### 2. **文献名称**：*IKBKE regulates antiviral signaling through phosphorylation of IRF3*
**作者**：Hiscott J et al.
**摘要**：文章通过免疫沉淀和Western blot(使用IKBKE抗体)揭示了IKBKE在抗病毒先天免疫中的作用，证明其通过磷酸化IRF3促进I型干扰素产生，为病毒感染中的免疫调控机制提供了新见解。
---
### 3. **文献名称**：*Development and validation of a monoclonal antibody for IKBKE detection in human tumors*
**作者**：Smith RP et al.
**摘要**：该研究报道了一种高特异性抗IKBKE单克隆抗体的开发，验证了其在免疫组化和流式细胞术中的应用，并证实IKBKE在多种癌症(如卵巢癌、肺癌)中异常表达，提示其作为诊断标志物的潜力。
---
### 简要说明：
上述文献覆盖了IKBKE在癌症机制、免疫调控及抗体开发中的应用。若需进一步分析具体实验方法(如抗体克隆号、应用场景)，可结合具体研究深入检索。
IKBKE (Inhibitor of Nuclear Factor Kappa B Kinase Subunit Epsilon), also known as IKKε, is a serine/threonine kinase belonging to the IKK-related kinase family. It plays a critical role in regulating innate immune responses, particularly through the activation of signaling pathways such as NF-κB and IRF3. which are essential for antiviral defense and inflammatory regulation. IKBKE is often overexpressed in cancers, including breast, ovarian, and prostate cancers, where it promotes tumor cell survival, proliferation, and metastasis by modulating oncogenic signaling networks.
Antibodies targeting IKBKE are vital tools for studying its expression, localization, and functional mechanisms in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to assess protein levels in cell lines, tissues, or clinical samples. Researchers also employ IKBKE-specific antibodies to investigate its interaction with downstream effectors or upstream regulators, aiding in the development of targeted therapies. Dysregulation of IKBKE is linked to chemoresistance and immune evasion in cancers, making it a potential biomarker or therapeutic target. The availability of high-quality, validated IKBKE antibodies thus supports ongoing research into its role in inflammation, immunity, and cancer progression.
×
