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Rabbit Polyclonal SPATA13 Antibody

  • 中文名: SPATA13抗体
  • 别    名: ASEF2; ARHGEF29; RP11-307N16.3
货号: IPDX00719
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

参考文献

以下是关于SPATA13抗体的假设性参考文献列表(注:以下内容为模拟示例,实际文献需通过学术数据库验证):

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1. **文献名称**: *SPATA13 regulates cell migration and adhesion through focal adhesion dynamics*

**作者**: Smith A, et al.

**摘要**: 本研究利用抗SPATA13抗体进行免疫荧光染色,揭示了SPATA13蛋白在调控细胞迁移和黏附中的作用机制,发现其通过影响黏着斑激酶(FAK)信号通路参与细胞骨架重组。

2. **文献名称**: *Characterization of a novel monoclonal antibody against SPATA13 for cancer metastasis studies*

**作者**: Chen L, et al.

**摘要**: 开发并验证了一种高特异性抗SPATA13单克隆抗体,通过Western blot和免疫组化证实其在多种癌细胞系中的表达升高,提示SPATA13可能在肿瘤转移中发挥关键作用。

3. **文献名称**: *SPATA13 expression in neural development: Insights from antibody-based localization*

**作者**: Garcia R, et al.

**摘要**: 使用抗SPATA13抗体对小鼠脑组织进行免疫染色,发现SPATA13在神经发育过程中动态表达,可能参与轴突导向和突触形成。

4. **文献名称**: *Functional analysis of SPATA13 in spermatogenesis using targeted antibody inhibition*

**作者**: Kim H, et al.

**摘要**: 通过抗SPATA13抗体阻断实验,证明SPATA13在精子发生过程中对减数分裂的调控功能,并利用免疫沉淀技术解析其互作蛋白网络。

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**备注**:以上文献信息为示例,实际研究中建议通过PubMed、Web of Science等平台以“SPATA13 antibody”或“SPATA13 immune localization”等关键词检索最新成果。

背景信息

The SPATA13 antibody targets the protein encoded by the SPATA13 gene (Spermatogenesis-Associated Protein 13), which is implicated in cellular processes such as cell migration, adhesion, and signaling. SPATA13. also known as ASEF2 (APC-Stimulated guanine nucleotide Exchange Factor 2), functions as a guanine nucleotide exchange factor (GEF) for Rac1 and Cdc42 GTPases, regulating cytoskeletal dynamics and cell polarity. It plays dual roles in cancer biology, acting as a metastasis promoter in certain cancers (e.g., colorectal) while showing tumor-suppressive activity in others. In reproductive biology, SPATA13 is linked to spermatogenesis, though its exact role remains under investigation. Antibodies against SPATA13 are utilized to study its expression, localization, and function in diverse contexts, including cancer progression, neuronal development, and male infertility. Commercial SPATA13 antibodies are typically validated for techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies explore its interaction with pathways like Wnt/β-catenin and its potential as a therapeutic target. Research using SPATA13 antibodies contributes to understanding its context-dependent roles in disease mechanisms and normal physiological processes.

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