| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYT9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是基于领域知识的假设性参考文献示例，供您参考。请注意，实际文献可能需要通过学术数据库(如PubMed、Google Scholar)检索确认：
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1. **文献名称**: *"Synaptotagmin-9 regulates insulin secretion in pancreatic β-cells"*
**作者**: Zhang L, et al.
**摘要**: 研究通过SYT9抗体检测其在β细胞中的表达，发现SYT9通过调控囊泡与细胞膜的融合影响胰岛素分泌，基因敲除后分泌功能受损。
2. **文献名称**: *"Characterization of a novel SYT9 antibody for synaptic vesicle tracking"*
**作者**: Müller R, et al.
**摘要**: 报道一种高特异性SYT9抗体的开发，验证其在免疫印迹和免疫组化中的应用，并用于神经元突触小泡的定位研究。
3. **文献名称**: *"SYT9 modulates dopamine release in Parkinson’s disease models"*
**作者**: Tanaka K, et al.
**摘要**: 利用SYT9抗体发现帕金森病模型中SYT9表达下调，可能与多巴胺能神经元分泌异常相关，提示其病理机制中的潜在作用。
4. **文献名称**: *"Synaptotagmin-9 interaction with SNARE proteins in exocytosis"*
**作者**: Johnson A, et al.
**摘要**: 通过免疫共沉淀(使用SYT9抗体)揭示SYT9与SNARE复合物的相互作用机制，阐明其在胞吐中的分子调控网络。
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**建议**：以上为模拟示例，实际文献需以具体研究为准。推荐使用关键词“SYT9 antibody”、“Synaptotagmin-9”在PubMed或Web of Science中检索，并筛选近年高被引论文或权威期刊文章。
The SYT9 antibody is a research tool designed to detect Synaptotagmin 9 (SYT9), a member of the synaptotagmin family of calcium-sensing proteins involved in membrane trafficking and synaptic transmission. SYT9 is characterized by two conserved C2 domains (C2A and C2B) that mediate calcium-dependent interactions with membranes and other proteins. While its paralogs, such as SYT1. are well-studied in neurotransmitter release, SYT9's precise biological role remains less defined. It is implicated in regulating hormone secretion, insulin exocytosis in pancreatic β-cells, and possibly vesicular transport in non-neuronal tissues.
SYT9 antibodies are typically developed using immunogenic peptides or recombinant protein fragments to ensure specificity. These antibodies are validated in applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study SYT9 expression, localization, and interaction partners. Researchers employ SYT9 antibodies to explore its involvement in diseases such as diabetes, neurodegenerative disorders, and cancer, where dysregulated vesicular trafficking may contribute to pathology. Recent studies also suggest SYT9's role in immune cell signaling, expanding its relevance beyond traditional secretory pathways. Quality validation, including knockout cell line controls, is critical to confirm antibody specificity, given the structural homology among synaptotagmin family members.
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