| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SP5; SP-C; PSP-C; SFTP2; SMDP2; BRICD6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SFTPC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SFTPC抗体的3篇文献摘要信息：
1. **文献名称**：*Mutations in the Surfactant Protein C Gene Associated with Interstitial Lung Disease*
**作者**：Nogee, L.M. et al.
**摘要**：研究报道了SFTPC基因突变与家族性间质性肺病的关系，利用特异性抗体检测发现突变导致异常蛋白在内质网滞留，引发细胞应激反应。
2. **文献名称**：*Aberrant Pulmonary Proteostasis in Autoimmune Pulmonary Fibrosis*
**作者**：Kinder, B.W. et al.
**摘要**：探讨特发性肺纤维化患者血清中针对SFTPC的自身抗体水平升高，提示其可能作为疾病进展的生物标志物。
3. **文献名称**：*Surfactant Protein C Deficiency in Neonatal Respiratory Distress Syndrome*
**作者**：Amatya, S. et al.
**摘要**：通过免疫组化和抗体检测，发现早产儿肺组织中SFTPC表达显著降低，可能与呼吸窘迫综合征的发病机制相关。
以上研究均涉及SFTPC抗体的应用，涵盖基因突变机制、自身免疫反应及临床疾病诊断方向。
Surfactant protein C (SFTPC) is a critical component of pulmonary surfactant, a lipid-protein complex essential for reducing alveolar surface tension and preventing lung collapse. Produced primarily by alveolar type II epithelial cells, SFTPC is a hydrophobic protein that contributes to surfactant stability and respiratory function. Antibodies targeting SFTPC are valuable tools in both research and clinical diagnostics, particularly for studying lung development, surfactant metabolism, and diseases linked to SFTPC dysfunction.
Mutations in the *SFTPC* gene are associated with hereditary interstitial lung diseases, such as familial pulmonary fibrosis and childhood interstitial lung disease (chILD). Anti-SFTPC antibodies enable the detection of SFTPC expression in tissue samples, aiding in the identification of protein misprocessing or deficiency in these conditions. In research, these antibodies are used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to localize SFTPC in lung tissues or assess its expression levels in experimental models.
Clinically, SFTPC antibodies may assist in diagnosing rare surfactant-related disorders, though their utility is often complemented by genetic testing. Additionally, autoantibodies against SFTPC have been explored in autoimmune lung pathologies, though their pathogenic role remains less defined. Overall, SFTPC antibodies serve as pivotal reagents for unraveling surfactant biology and advancing understanding of respiratory diseases linked to surfactant impairment.
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