| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | IPCA7, IPCA-7, SYTVII, PCANAP7, SYT-VII |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SYT7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYT7抗体的3篇示例参考文献(内容为模拟示例，仅供参考)：
1. **"Synaptotagmin VII regulates calcium-dependent insulin secretion in pancreatic islet β-cells"**
- **作者**: Gao, X., & Zhang, Y.
- **摘要**: 本研究利用SYT7抗体通过免疫印迹和免疫荧光技术，证实SYT7在胰岛β细胞中调控钙依赖性的胰岛素分泌，其缺失导致葡萄糖刺激的胰岛素释放减少。
2. **"SYT7 mediates synaptic vesicle docking and plasticity in hippocampal neurons"**
- **作者**: Wang, L., et al.
- **摘要**: 通过SYT7抗体的免疫组织化学分析，发现SYT7在海马神经元突触小泡锚定中起关键作用，并参与长时程增强(LTP)的调控。
3. **"SYT7 promotes lysosomal exocytosis and cell invasion in breast cancer"**
- **作者**: Li, J., & Chen, M.
- **摘要**: 研究使用SYT7抗体检测乳腺癌细胞中SYT7的表达，发现其通过介导溶酶体与质膜融合促进肿瘤细胞侵袭和转移。
**注意**：以上文献信息为示例，实际文献需通过PubMed、Web of Science或Google Scholar等平台检索关键词(如"SYT7 antibody"、"Synaptotagmin-7 function")。
The SYT7 antibody is a crucial tool for studying Synaptotagmin-7 (SYT7), a calcium-sensing protein belonging to the synaptotagmin family. SYT7 is widely expressed in tissues, particularly in the brain, endocrine cells, and immune cells, where it regulates membrane trafficking, vesicle fusion, and calcium-dependent exocytosis. It plays roles in diverse physiological processes, including synaptic transmission, lysosomal exocytosis, and plasma membrane repair. The SYT7 antibody specifically detects SYT7 protein isoforms, enabling researchers to investigate its expression, localization, and function in cellular and animal models.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes knockout controls to confirm specificity. Research applications span neuroscience (studying synaptic plasticity or neurodegenerative diseases), endocrinology (hormone secretion mechanisms), and immunology (immune cell secretion pathways). SYT7 dysregulation has been linked to conditions such as diabetes, cancer metastasis, and neuronal disorders, making the antibody valuable for exploring disease mechanisms.
Developed in various host species (e.g., rabbit, mouse), SYT7 antibodies are available as monoclonal or polyclonal forms, with selection depending on experimental needs. Proper validation ensures minimal cross-reactivity with other synaptotagmin family members (e.g., SYT1. SYT4), which share structural homology but distinct functions. Overall, SYT7 antibodies are indispensable for deciphering SYT7’s role in cellular communication and pathology.
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