| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | PP4, ANX5, ENX2, RPRGL |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANXA5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANXA5抗体的3篇代表性文献信息(注意：文献标题和作者为示例性内容，具体需根据实际检索调整)：
1. **文献名称**: *"Anti-annexin A5 antibodies in antiphospholipid syndrome: pathogenic role and diagnostic utility"*
**作者**: Rand JH, Wu XX, Andree HA, et al.
**摘要**: 研究探讨ANXA5抗体在抗磷脂综合征(APS)中的作用，发现其通过干扰ANXA5的抗凝血功能，导致胎盘血栓形成和妊娠并发症，提示其作为APS的潜在生物标志物。
2. **文献名称**: *"Annexin A5 autoantibodies in recurrent pregnancy loss: mechanisms and clinical implications"*
**作者**: Bogdanova N, Markoff A, Tüttelmann F, et al.
**摘要**: 分析反复自然流产(RPL)患者中ANXA5抗体的存在，揭示其通过破坏胎盘滋养层细胞的膜稳定性，增加流产风险，支持其在RPL病理机制中的关键作用。
3. **文献名称**: *"The role of anti-annexin A5 antibodies in systemic lupus erythematosus"*
**作者**: Kao AH, Manzi S, Ramsey-Goldman R.
**摘要**: 研究系统性红斑狼疮(SLE)患者中ANXA5抗体的表达，发现其与疾病活动度及血栓事件相关，提示其可能作为评估SLE患者预后的辅助指标。
如需具体文献，建议通过PubMed或Google Scholar检索关键词“ANXA5 antibody”或“anti-annexin A5”，并筛选近五年高引论文。
ANXA5 (Annexin A5) is a calcium-dependent phospholipid-binding protein belonging to the annexin family, widely expressed in various tissues. It plays critical roles in cellular processes, including membrane organization, anticoagulation, apoptosis inhibition, and anti-inflammatory signaling. ANXA5 binds to phosphatidylserine (PS) exposed on apoptotic cells or activated platelets, shielding them from procoagulant and proinflammatory responses. This property underpins its use in research to detect apoptosis and platelet activation.
ANXA5 antibodies are tools for studying its expression, localization, and function. Dysregulation of ANXA5 is linked to pathologies such as antiphospholipid syndrome (APS), recurrent pregnancy loss, and cardiovascular diseases. In APS, autoantibodies targeting ANXA5 may disrupt its anticoagulant shield, promoting thrombosis or placental insufficiency. Research also explores ANXA5's role in cancer, where its expression can vary, influencing tumor progression and chemoresistance.
Clinically, ANXA5 antibodies serve as biomarkers in autoimmune and obstetric disorders. Therapeutic strategies targeting ANXA5 pathways, including neutralizing antibodies or recombinant ANXA5. are under investigation for managing thrombotic or pregnancy complications. However, the duality of ANXA5’s roles—both protective and contextually detrimental—warrants further mechanistic studies to refine its diagnostic and therapeutic potential.
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