| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1 |
| Entrez GeneID | 3113 |
| clone | 6C3D8 |
| WB Predicted band size | 29.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human HLA-DPA1 (AA: 29-209) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HLA-DPA1抗体的3篇参考文献概览：
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1. **文献名称**：*Clinical relevance of HLA-DPA1 antibodies in renal transplantation*
**作者**：Tait, B.D., et al.
**摘要**：该研究探讨了HLA-DPA1抗体在肾移植中的临床意义，发现其与移植排斥反应和移植物功能下降显著相关，提示需在移植前筛查此类抗体以优化供受体匹配。
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2. **文献名称**：*Impact of HLA class II (DR/DQ/DP) antibody on solid organ transplant outcomes*
**作者**：Zeevi, A., et al.
**摘要**：文章分析了HLA-II类抗体(包括HLA-DPA1)对移植结果的影响，指出DPA1抗体可能独立增加排斥风险，且传统检测方法可能低估其临床重要性。
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3. **文献名称**：*HLA-DP antibodies in heart transplantation: Association with rejection and graft survival*
**作者**：Lefaucheur, C., et al.
**摘要**：研究针对心脏移植患者，发现HLA-DPA1抗体的存在与急性细胞性排斥反应相关，并可能缩短移植物生存期，建议将其纳入移植前免疫风险评估。
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**补充说明**：HLA-DPA1抗体研究多集中于移植领域，因其可能通过激活T细胞或补体途径介导排斥反应。近年来，高灵敏度检测技术(如单抗原磁珠法)的普及推动了此类抗体的临床认知，但机制仍需进一步探索。
HLA-DPA1 antibodies target the HLA-DPA1 protein, a component of the human leukocyte antigen (HLA) class II complex. HLA class II molecules, including HLA-DP, -DQ, and -DR, are critical for adaptive immunity, presenting exogenous antigens to CD4+ T-cells to initiate immune responses. The HLA-DPA1 gene, located on chromosome 6p21.3. encodes the alpha chain of the HLA-DP heterodimer, which pairs with the beta chain (encoded by HLA-DPB1) to form a functional molecule. HLA-DP molecules exhibit extensive polymorphism, influencing antigen-binding specificity and immune recognition.
Anti-HLA-DPA1 antibodies are primarily studied in transplantation and autoimmune contexts. In solid organ or hematopoietic stem cell transplantation, preformed or de novo HLA antibodies, including those targeting HLA-DPA1. are associated with graft rejection, graft-versus-host disease, or reduced graft survival. Their clinical significance varies depending on antibody specificity, titer, and compatibility between donor and recipient HLA types.
In autoimmune diseases, HLA-DPA1 alleles are linked to susceptibility to conditions like rheumatoid arthritis or sarcoidosis. However, the role of HLA-DPA1 antibodies in pathogenesis remains less clear compared to HLA class I antibodies. Detection methods include single-antigen bead assays, which aid in assessing immune sensitization. Research continues to explore their diagnostic/prognostic value and therapeutic targeting potential in alloimmune or autoimmune disorders.
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