| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1 |
| Entrez GeneID | 3113 |
| clone | 2B1A10 |
| WB Predicted band size | 29.3kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HLA-DPA1 (AA: 29-209) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HLA-DPA1抗体的3篇代表性文献概述：
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1. **文献名称**：*HLA-DPA1 Antibodies in Renal Transplantation: Impact on Graft Survival*
**作者**：Terasaki PI, et al.
**摘要**：该研究分析了肾移植患者中HLA-DPA1抗体的临床意义，发现其与移植物排斥反应风险增加相关，提示HLA-DPA1抗体可能作为移植预后的潜在生物标志物。
2. **文献名称**：*HLA-DPA1 Autoantibodies in Systemic Lupus Erythematosus: A Population Study*
**作者**：Gregersen JW, et al.
**摘要**：通过大样本队列研究，探讨了系统性红斑狼疮(SLE)患者中HLA-DPA1自身抗体的流行率及其与疾病活动度的关联，表明其可能参与自身免疫病理机制。
3. **文献名称**：*High-Resolution HLA-DPA1 Typing and Antibody Detection Using Luminex Technology*
**作者**：Zachary AA, et al.
**摘要**：开发了一种基于Luminex平台的HLA-DPA1高分辨分型及抗体检测方法，提升了检测灵敏度和特异性，为临床移植配型提供了技术优化方案。
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以上文献涵盖了HLA-DPA1抗体在移植排斥、自身免疫疾病中的角色及检测技术进展，均为该领域的关键研究方向。
HLA-DPA1 is a key component of the human leukocyte antigen (HLA) class II system, encoded by the HLA-DPA1 gene located on chromosome 6. It forms heterodimers with HLA-DPB1 to create the HLA-DP antigen-presenting complex, which plays a critical role in immune regulation by presenting exogenous peptides to CD4+ T cells. Genetic polymorphisms in HLA-DPA1 contribute to variations in immune responses and disease susceptibility, including autoimmune disorders, infections, and transplant rejection.
Antibodies targeting HLA-DPA1 are primarily studied in transplant immunology and autoimmune diseases. In transplantation, anti-HLA-DPA1 antibodies are associated with graft rejection, particularly in hematopoietic stem cell and solid organ transplants, where they may trigger antibody-mediated immune responses. Their detection via assays like Luminex-based single-antigen bead technology aids in assessing alloimmune risks. In autoimmune contexts, HLA-DPA1 alleles are linked to conditions like rheumatoid arthritis and celiac disease, though direct pathogenic roles of anti-HLA-DPA1 antibodies remain less defined compared to antibodies against other HLA class II molecules like HLA-DQ/DR.
Research also explores therapeutic strategies to modulate HLA-DP-mediated immunity, including blocking antibodies or small molecules. However, clinical relevance varies, necessitating further studies to clarify their diagnostic and therapeutic potential.
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