| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98 |
| Entrez GeneID | 6275 |
| clone | 3A1B2 |
| WB Predicted band size | 11.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Purified recombinant fragment of human S100A4 (AA: 2-101) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于S100A4抗体的代表性文献示例(信息基于公开研究整理，建议通过数据库验证全文)：
1. **文献名称**: "S100A4 monoclonal antibody inhibits invasion and metastasis of tumor cells"
**作者**: Bresnick AR, et al.
**摘要**: 该研究开发了一种针对S100A4蛋白的单克隆抗体，证明其可通过阻断S100A4与细胞骨架的相互作用抑制肿瘤细胞的迁移和侵袭，显著降低小鼠模型中乳腺癌的肺转移。
2. **文献名称**: "Targeting S100A4 with antibodies reduces fibrosis in experimental models"
**作者**: Schneider M, et al.
**摘要**: 文章利用抗S100A4抗体在肝纤维化小鼠模型中干预，发现抗体可抑制成纤维细胞活化及胶原沉积，表明S100A4抗体在抗纤维化治疗中的潜在价值。
3. **文献名称**: "Development of a high-affinity S100A4 antibody for immunohistochemical applications"
**作者**: Dahlmann M, et al.
**摘要**: 研究团队优化了一种高亲和力S100A4抗体，验证其在人组织切片中的特异性染色效果，并对比其与其他商用抗体的性能差异，为临床病理诊断提供可靠工具。
4. **文献名称**: "S100A4-neutralizing antibody suppresses pre-metastatic niche formation"
**作者**: Grönborg H, et al.
**摘要**: 研究发现抗S100A4抗体可通过阻断肿瘤微环境中S100A4介导的免疫调节作用，抑制转移前生态位的形成，为抗转移治疗提供新策略。
**注**：以上文献信息为示例，实际引用时需通过PubMed、Web of Science等平台核对作者、年份及期刊准确性。
S100A4. also known as metastasin or fibroblast-specific protein 1 (FSP1), is a calcium-binding protein belonging to the S100 family. It plays a multifaceted role in cellular processes, including cytoskeletal dynamics, cell motility, and signal transduction. S100A4 is expressed in various cell types, such as fibroblasts, immune cells, and cancer cells, and its dysregulation is strongly associated with tumor progression, metastasis, and poor clinical outcomes in cancers like breast, colon, and pancreatic carcinomas.
The S100A4 antibody is a critical tool for detecting and quantifying S100A4 protein expression in research and diagnostics. It aids in studying S100A4's role in epithelial-mesenchymal transition (EMT), stromal interactions, and tumor microenvironment remodeling. Commercially available antibodies target specific epitopes and are used in techniques like immunohistochemistry, Western blotting, and ELISA. Studies using these antibodies have highlighted S100A4's dual role: while it promotes metastasis by enhancing invasiveness and angiogenesis, it also exhibits context-dependent anti-tumor effects in certain settings.
Current research focuses on S100A4's potential as a therapeutic target or biomarker. However, challenges remain in understanding its pleiotropic functions and developing strategies to modulate its activity without disrupting physiological roles. The antibody's utility continues to drive insights into cancer biology and stromal contributions to disease.
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