| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DRRS; HSAL4; ZNF797; dJ1112F19.1 |
| Entrez GeneID | 57167 |
| clone | 2D4F5 |
| WB Predicted band size | 112.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SALL4 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于SALL4抗体的3篇代表性文献的简要信息：
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1. **文献名称**: **"SALL4 is a novel diagnostic marker for testicular germ cell tumors"**
**作者**: Lee et al. (2003)
**摘要**: 该研究首次提出SALL4抗体在睾丸生殖细胞肿瘤(如精原细胞瘤和胚胎性癌)中高表达，可作为敏感且特异的免疫组化标记物，帮助区分生殖细胞肿瘤与其他类型的癌症。
2. **文献名称**: **"SALL4 expression in hepatocellular carcinoma predicts poor prognosis"**
**作者**: Yang et al. (2012)
**摘要**: 研究发现SALL4在肝细胞癌(HCC)中异常表达，且与肿瘤侵袭性、转移及患者生存率降低显著相关，提示SALL4抗体在肝癌预后评估中的潜在价值。
3. **文献名称**: **"SALL4 as a biomarker for myelodysplastic syndromes and acute myeloid leukemia"**
**作者**: Wang et al. (2010)
**摘要**: 该文献证实SALL4在骨髓增生异常综合征(MDS)和急性髓系白血病(AML)中异常激活，其抗体可用于辅助诊断及监测疾病进展，尤其在难治性病例中表现突出。
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这些文献涵盖了SALL4抗体在生殖系统肿瘤、实体瘤(肝癌)及血液系统恶性肿瘤中的诊断和预后应用，反映了其多领域的临床价值。如需具体文章链接或补充，可进一步说明!
SALL4 antibody is a diagnostic and research tool targeting the SALL4 protein, a transcription factor critical in embryonic development and stem cell maintenance. Belonging to the Spalt-like (SAL) family, SALL4 plays a key role in regulating pluripotency, cell fate determination, and organogenesis, particularly in germ cells and hematopoietic stem cells. Its expression is normally restricted to fetal tissues but is aberrantly reactivated in various cancers, making it a valuable biomarker.
In diagnostic pathology, SALL4 antibody is widely used as an immunohistochemical marker for germ cell tumors (e.g., seminomas, yolk sac tumors) and certain somatic malignancies, including subsets of hepatocellular carcinoma, gastric cancer, and myeloid neoplasms. Its nuclear staining pattern helps distinguish these tumors from morphological mimics.
Research applications focus on SALL4's oncogenic role, as it promotes tumor proliferation, metastasis, and therapy resistance by modulating Wnt/β-catenin, PTEN, and other pathways. Additionally, SALL4 antibodies aid in studying developmental biology, particularly in models of stem cell differentiation and tissue regeneration.
Commercially available SALL4 antibodies are typically raised against epitopes in its conserved zinc finger domains. However, interpretation requires caution, as low-level expression may occur in normal tissues. Clinically, SALL4 overexpression often correlates with poor prognosis, highlighting its dual utility as a diagnostic tool and potential therapeutic target.
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