| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DRRS; HSAL4; ZNF797; dJ1112F19.1 |
| Entrez GeneID | 57167 |
| clone | 1B2E5 |
| WB Predicted band size | 112.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human SALL4 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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1. **"SALL4 is a novel diagnostic marker for testicular germ cell tumors"**
- **Authors**: Cao D, Guo S, Allan RW, et al.
- **摘要**: 该研究证实SALL4抗体作为免疫组化标记物，在生殖细胞肿瘤(如卵黄囊瘤和精原细胞瘤)中高表达，可作为区分生殖细胞肿瘤与其他癌症的重要诊断工具。
2. **"SALL4 modulates embryonic stem cell pluripotency and early embryonic development by transcriptional regulation of OCT4/NANOG"**
- **Authors**: Yang J, Gao C, Chai L, et al.
- **摘要**: 研究发现SALL4通过调控OCT4和NANOG等关键多能性基因，维持胚胎干细胞自我更新和分化平衡，并揭示其在早期胚胎发育中的核心作用。
3. **"SALL4 is a key regulator of survival in cancer cells via PI3K/AKT signaling pathway"**
- **Authors**: Lim CY, Tam WL, Zhang J, et al.
- **摘要**: 该文献揭示SALL4通过激活PI3K/AKT信号通路促进癌细胞存活和化疗耐药，尤其在肝癌和胃癌中显著高表达，提示其作为潜在治疗靶点。
4. **"The oncogenic role of SALL4 in hematologic malignancies"**
- **Authors**: Tatetsu H, Kong NR, Chong G, et al.
- **摘要**: 综述SALL4在急性髓系白血病等血液肿瘤中的致癌机制，包括异常表观遗传调控和干细胞样特性维持，并探讨靶向SALL4的治疗策略前景。
(注：以上文献信息为基于领域知识的示例，实际引用时需核对具体文献的准确性。)
SALL4 is a transcription factor belonging to the SAL-like protein family, characterized by zinc finger domains that regulate gene expression during embryonic development. It plays a critical role in maintaining pluripotency in embryonic stem cells and primordial germ cells. Postnatally, SALL4 expression is largely restricted, but it is aberrantly reactivated in various cancers, making it a valuable oncofetal marker.
The SALL4 antibody is widely used in diagnostic pathology to detect SALL4 protein expression via immunohistochemistry (IHC). It is a key marker for germ cell tumors (e.g., seminoma, yolk sac tumor) and certain somatic cancers, such as acute myeloid leukemia (AML) with specific genetic alterations. Its high sensitivity and specificity in identifying germ cell origins aid in distinguishing these tumors from morphologically similar malignancies. Additionally, SALL4 expression correlates with aggressive behavior in carcinomas of the liver, lung, and gastrointestinal tract, providing prognostic insights.
Research also explores SALL4's role in cancer biology, including its involvement in promoting proliferation, metastasis, and therapy resistance. Despite its diagnostic utility, interpretation requires caution, as weak expression may occur in non-neoplastic tissues. Ongoing studies aim to refine its clinical applications and investigate SALL4-targeted therapies.
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