| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | LRP-1B; LRPDIT; LRP-DIT |
| Entrez GeneID | 53353 |
| clone | 8A8D12 |
| WB Predicted band size | 515.5kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LRP1B (AA: extra 25-161) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于LRP1B抗体的3篇参考文献示例(注：文献为假设性示例，实际需根据真实文献调整)：
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1. **文献名称**: *LRP1B as a Tumor Suppressor in Gastric Cancer: Insights from Antibody-Based Protein Expression Analysis*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用商业化LRP1B特异性抗体，通过免疫组化(IHC)和Western blot技术，发现LRP1B蛋白在胃癌组织中表达显著下调，且与患者预后不良相关，支持其作为肿瘤抑制基因的功能。
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2. **文献名称**: *Epigenetic Silencing of LRP1B in Colorectal Cancer: Validation by ChIP and Immunohistochemistry*
**作者**: Tanaka K, et al.
**摘要**: 通过染色质免疫沉淀(ChIP)和LRP1B抗体介导的免疫荧光分析，揭示了结直肠癌中LRP1B启动子区域的异常甲基化导致其转录抑制，为表观遗传治疗提供潜在靶点。
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3. **文献名称**: *Antibody-Based Profiling of LRP1B Mutations in Non-Small Cell Lung Cancer*
**作者**: Wang X, et al.
**摘要**: 使用多克隆LRP1B抗体对肺癌组织进行免疫组化分析，结合基因组测序，发现LRP1B突变与蛋白表达缺失相关，提示其作为生物标志物在肺癌精准治疗中的应用潜力。
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**提示**：实际文献需通过PubMed或Google Scholar检索关键词“LRP1B antibody”、“LRP1B immunohistochemistry”等获取。建议关注近年研究(如2018-2023年)及高影响力期刊(如*Nature Cancer*, *Clinical Cancer Research*)。
LRP1B (Low-Density Lipoprotein Receptor-Related Protein 1B) is a member of the LDL receptor family, primarily known for its role as a putative tumor suppressor. The *LRP1B* gene, located on chromosome 2q21.2. is frequently subject to genomic deletions or epigenetic silencing in various cancers, including lung, breast, and gastric cancers. The encoded protein shares structural homology with LRP1. featuring ligand-binding domains, epidermal growth factor (EGF) repeats, and transmembrane regions. LRP1B is implicated in cellular processes such as endocytosis, signal transduction, and modulation of pathways like Wnt/β-catenin and STAT3. which are critical in tumorigenesis and metastasis.
Antibodies targeting LRP1B are essential tools for studying its expression, localization, and functional mechanisms. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to assess LRP1B protein levels in tissues or cell lines, often revealing downregulation in malignancies. Such antibodies also aid in exploring LRP1B’s interaction partners and its role in cancer suppression, such as inhibiting cell proliferation or invasion. Clinically, LRP1B antibodies have potential diagnostic and prognostic applications, as reduced LRP1B expression correlates with advanced tumor stages and poor patient outcomes. However, challenges remain in standardizing antibodies due to LRP1B’s large size and post-translational modifications. Ongoing research focuses on validating these antibodies for therapeutic targeting or as biomarkers in precision oncology.
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