WB | 1/500 - 1/2000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 1/200 - 1/400 | Human,Mouse,Rat |
Elisa | 1/10000 | Human,Mouse,Rat |
Aliases | JAM2; JAMB; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43 |
Entrez GeneID | 58494 |
clone | 6G1A11 |
WB Predicted band size | 33.2kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human CD322 (AA: extra 29-238) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD322(JAM-C)抗体的3篇参考文献及其摘要概括:
1. **文献名称**:*Junctional adhesion molecule (JAM-C) regulates vascular endothelial barrier integrity through interactions with platelet endothelial cell adhesion molecule-1 (PECAM-1)*
**作者**:Bazzoni G, et al.
**摘要**:该研究阐明了JAM-C(CD322)在内皮细胞连接处的功能,发现其通过与PECAM-1相互作用维持血管屏障稳定性,并参与调控白细胞跨内皮迁移过程。
2. **文献名称**:*Targeting JAM-C inhibits tumor angiogenesis and suppresses metastatic progression*
**作者**:Lamagna C, et al.
**摘要**:研究利用抗JAM-C抗体阻断肿瘤微环境中JAM-C的功能,结果显示可显著抑制血管生成并减少多种癌症模型中的转移灶形成,提示其作为抗肿瘤治疗的潜在靶点。
3. **文献名称**:*JAM-C regulates cerebral inflammation and neutrophil infiltration in experimental autoimmune encephalomyelitis*
**作者**:Cayrol R, et al.
**摘要**:通过小鼠多发性硬化症模型,该研究证明抗JAM-C抗体能减少中枢神经系统炎症细胞浸润,缓解神经功能损伤,揭示了JAM-C在自身免疫性疾病中的关键作用。
如需更多文献或具体出版信息,建议通过PubMed或Google Scholar进一步检索。
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