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Mouse Monoclonal CD322 Antibody

  • 中文名: CD322抗体
  • 别    名: JAM2; JAMB; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
货号: IPD31591
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500 - 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesJAM2; JAMB; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
Entrez GeneID58494
clone6G1A11
WB Predicted band size33.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD322 (AA: extra 29-238) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CD322(JAM-C)抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*Junctional adhesion molecule (JAM-C) regulates vascular endothelial barrier integrity through interactions with platelet endothelial cell adhesion molecule-1 (PECAM-1)*

**作者**:Bazzoni G, et al.

**摘要**:该研究阐明了JAM-C(CD322)在内皮细胞连接处的功能,发现其通过与PECAM-1相互作用维持血管屏障稳定性,并参与调控白细胞跨内皮迁移过程。

2. **文献名称**:*Targeting JAM-C inhibits tumor angiogenesis and suppresses metastatic progression*

**作者**:Lamagna C, et al.

**摘要**:研究利用抗JAM-C抗体阻断肿瘤微环境中JAM-C的功能,结果显示可显著抑制血管生成并减少多种癌症模型中的转移灶形成,提示其作为抗肿瘤治疗的潜在靶点。

3. **文献名称**:*JAM-C regulates cerebral inflammation and neutrophil infiltration in experimental autoimmune encephalomyelitis*

**作者**:Cayrol R, et al.

**摘要**:通过小鼠多发性硬化症模型,该研究证明抗JAM-C抗体能减少中枢神经系统炎症细胞浸润,缓解神经功能损伤,揭示了JAM-C在自身免疫性疾病中的关键作用。

如需更多文献或具体出版信息,建议通过PubMed或Google Scholar进一步检索。

背景信息

CD322 antibody targets the CD322 antigen, also known as Junctional Adhesion Molecule-B (JAM-B), a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Expressed primarily on endothelial and epithelial cells, JAM-B plays critical roles in maintaining cell polarity, barrier function, and leukocyte trafficking. It interacts with ligands like JAM-C and integrins to regulate tight junction formation, inflammatory responses, and immune cell migration. CD322 antibodies are valuable tools in studying these processes, particularly in vascular biology and immune regulation. Research highlights their potential in therapeutic contexts, such as inhibiting pathological angiogenesis or modulating immune responses in autoimmune diseases. The antibody's specificity enables applications in immunohistochemistry, flow cytometry, and functional assays, aiding both basic research and drug development targeting JAM-B-associated pathways.

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