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Mouse Monoclonal CD170 Antibody

  • 中文名： CD170抗体
  • 别    名： SIGLEC5; OBBP2; CD33L2; OB-BP2; SIGLEC-5
货号: IPD31588
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesSIGLEC5; OBBP2; CD33L2; OB-BP2; SIGLEC-5
Entrez GeneID8778
clone3F5A3
WB Predicted band size60.7kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD170 (AA: extra 17-230) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CD170(Siglec-5)抗体的模拟参考文献示例(非真实文献，仅供格式参考)：

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1. **文献名称**：*CD170 Antibody-Mediated Inhibition of Siglec-5 Enhances Neutrophil Anti-Tumor Activity*

**作者**：Smith A, et al.

**摘要**：研究通过体外实验证明，靶向CD170的单克隆抗体可阻断Siglec-5在中性粒细胞上的免疫抑制信号，增强其对肿瘤细胞的杀伤能力，为癌症免疫治疗提供新策略。

2. **文献名称**：*Structural Characterization of Human Siglec-5 and Its Interaction with CD170-Specific Antibodies*

**作者**：Wang L, et al.

**摘要**：利用X射线晶体学解析了CD170(Siglec-5)的分子结构，并揭示了特定抗体结合表位，为开发高亲和力诊断或治疗性抗体奠定结构基础。

3. **文献名称**：*CD170 as a Potential Biomarker in Myeloid Leukemia: Insights from Antibody-Based Detection*

**作者**：Garcia R, et al.

**摘要**：临床研究发现，CD170在急性髓系白血病细胞中高表达，其抗体检测可作为疾病分型和预后的生物标志物，与患者化疗耐药性相关。

4. **文献名称**：*Siglec-5 Antibody Modulates Inflammatory Response in Sepsis Models*

**作者**：Kim J, et al.

**摘要**：在脓毒症小鼠模型中，抗CD170抗体通过调控巨噬细胞炎症因子释放，减轻全身炎症反应，提示其在脓毒症治疗中的潜在应用。

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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如“CD170 antibody”、“Siglec-5 therapeutic”)。

背景信息

The CD170 antibody targets Siglec-5 (sialic acid-binding immunoglobulin-type lectin-5), a cell surface protein belonging to the Siglec family, which plays roles in immune modulation by recognizing sialylated glycans. Expressed primarily on myeloid cells, such as neutrophils and macrophages, Siglec-5 interacts with sialic acid-containing ligands to regulate immune responses, often dampening activation to maintain tolerance or prevent excessive inflammation. CD170/Siglec-5 is implicated in both physiological and pathological processes, including cancer immune evasion, as some tumors exploit its inhibitory signaling to suppress anti-tumor immunity. In research, CD170 antibodies are used as tools to study Siglec-5's function in diseases like leukemia, autoimmune disorders, and chronic inflammation. Monoclonal antibodies against CD170 enable detection of protein expression via flow cytometry or immunohistochemistry, while blocking antibodies help investigate its immunosuppressive role. Therapeutic potential is also explored, with antibody-based strategies aiming to either block inhibitory signals in cancer or modulate immune activity in autoimmunity. Challenges include understanding context-dependent roles, as Siglec-5 may exhibit dual functions in different microenvironments. Overall, CD170 antibodies serve as critical reagents in deciphering immune regulation mechanisms and developing targeted therapies.

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