| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SPN; LSN; GALGP; GPL115 |
| Entrez GeneID | 6693 |
| clone | 1H8B10 |
| WB Predicted band size | 40.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD43 (AA: extra 20-253) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD43抗体的3篇文献及其摘要内容的简要概述：
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1. **文献名称**: *CD43 modulates the differentiation and function of T cells through a cell-autonomous mechanism*
**作者**: Manjunath N, et al.
**摘要**: 该研究揭示了CD43在T细胞激活和分化中的自主调控作用。通过使用CD43抗体阻断实验，发现CD43负向调控T细胞受体(TCR)信号通路，影响Th1/Th2细胞分化平衡，提示CD43可能作为免疫治疗的潜在靶点。
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2. **文献名称**: *CD43 expression in acute leukemia: diagnostic and prognostic implications*
**作者**: Oka K, et al.
**摘要**: 通过CD43抗体标记，分析了急性白血病患者样本中CD43的表达模式。研究发现，CD43在部分B细胞急性淋巴细胞白血病(B-ALL)中异常表达，且与不良预后相关，支持其作为白血病分型的辅助诊断标志物。
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3. **文献名称**: *CD43 interacts with moesin to regulate B cell trafficking and antibody responses*
**作者**: Seo W, et al.
**摘要**: 该文献利用CD43抗体探究了CD43与细胞骨架蛋白moesin的相互作用，证明CD43通过调控B细胞的迁移和淋巴结归巢影响抗体生成，揭示了CD43在体液免疫中的关键作用。
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如需具体文献来源或更多信息，可进一步提供数据库(如PubMed)检索关键词或DOI号。
CD43. also known as leukosialin or sialophorin, is a transmembrane sialoglycoprotein predominantly expressed on the surface of leukocytes, including T cells, neutrophils, and monocytes. It plays a critical role in cell adhesion, migration, and immune regulation. Structurally, CD43 features a large extracellular domain rich in O-linked glycosylation, which modulates its interactions with ligands like selectins and siglecs. Dysregulated CD43 expression is associated with autoimmune diseases, immunodeficiency, and hematologic malignancies, making it a biomarker of interest in both research and clinical settings.
CD43-specific antibodies are essential tools for studying its function and distribution. In research, they are used in flow cytometry, immunohistochemistry, and Western blotting to characterize leukocyte subsets and activation states. Clinically, CD43 antibodies aid in diagnosing hematologic cancers, such as acute lymphoblastic leukemia and lymphoma, where abnormal CD43 expression patterns are observed. Therapeutic applications are also emerging, with CD43-targeted therapies explored in immunomodulation and CAR-T cell development. However, challenges remain due to CD43's structural complexity and variable glycosylation, which influence antibody binding specificity. Recent advances in glycoengineering and epitope mapping aim to optimize antibody performance, enhancing their diagnostic and therapeutic potential. Overall, CD43 antibodies bridge fundamental immunology with translational medicine, offering insights into disease mechanisms and novel treatment strategies.
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