| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MCP; TLX; AHUS2; MIC10; TRA2.10 |
| Entrez GeneID | 4179 |
| clone | 1A5A5 |
| WB Predicted band size | 43.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD46抗体的3篇代表性文献及其简要摘要(基于公开信息模拟，建议通过学术数据库核实原文)：
1. **文献名称**：*CD46: A 'Pathogenic' Receptor with Therapeutic Potential*
**作者**：John P. Atkinson, Timothy S. C. Hsieh
**摘要**：该综述讨论了CD46作为补体调节蛋白的生物学功能，并重点探讨其在麻疹病毒、腺病毒感染中的作用机制，以及开发靶向CD46的单克隆抗体在抗病毒治疗及癌症免疫疗法中的潜力。
2. **文献名称**：*Targeting CD46 enhances anti-tumor T cell immunity in triple-negative breast cancer*
**作者**：Zheng Xia, et al.
**摘要**：本研究通过实验证明，使用阻断型CD46抗体可抑制肿瘤微环境中补体过度激活，从而增强T细胞对三阴性乳腺癌的杀伤效果，为CD46抗体在实体瘤免疫治疗中的应用提供依据。
3. **文献名称**：*Structural basis of CD46 recognition by human adenovirus type 11 fiber knob*
**作者**：Xing Zhang, et al.
**摘要**：利用冷冻电镜技术解析了CD46与腺病毒11型纤维蛋白复合体的结构，揭示了CD46的抗原表位特征，为设计靶向CD46的中和抗体或基因递送载体提供了分子基础。
4. **文献名称**：*CD46 costimulation induces regulatory T cells and inhibits pathogenic Th17 responses*
**作者**：Claudia Kemper, et al.
**摘要**：研究证明CD46信号通路在T细胞活化中具有双重调节作用，特定抗体可激活CD46下游通路诱导调节性T细胞分化，为治疗多发性硬化症等Th17相关自身免疫疾病提供新策略。
(注：以上为示例性内容，实际文献需通过PubMed/Google Scholar等平台检索确认。)
CD46. also known as membrane cofactor protein (MCP), is a transmembrane regulatory protein widely expressed on nucleated human cells. It belongs to the complement regulatory protein family and plays a critical role in preventing unintended complement-mediated damage to host cells by binding to complement proteins C3b and C4b, facilitating their inactivation. Beyond its immune regulatory function, CD46 serves as a receptor for several pathogens, including measles virus, human herpesvirus 6. and certain adenoviruses, enabling their cellular entry.
CD46 antibodies are tools or therapeutics targeting this protein. In research, they are used to study CD46's roles in immune modulation, viral pathogenesis, and cell signaling. Clinically, CD46 has gained attention due to its overexpression in various cancers, making it a potential therapeutic target. Antibodies against CD46 are explored in cancer immunotherapy, either to block pro-survival signals in tumors or to deliver cytotoxic agents selectively. Additionally, CD46 antibodies have implications in autoimmune diseases and reproductive medicine, given its involvement in sperm-egg interaction and pregnancy-related immune tolerance.
The development of CD46-specific monoclonal antibodies (e.g., M177) has advanced both diagnostic and therapeutic applications. Challenges include managing CD46's ubiquitous expression to minimize off-target effects. Ongoing studies aim to refine antibody specificity and explore bispecific designs to enhance therapeutic efficacy in oncology and infectious diseases.
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