| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ITGA3; VL3A; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3 |
| Entrez GeneID | 3675 |
| clone | 5F1D4 |
| WB Predicted band size | 116.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD49C (AA: extra 63-248) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD49c(整合素α3)抗体的参考文献示例(注：以下为假设性示例，具体文献需通过学术数据库查询)：
1. **标题**：*Role of Integrin α3β1 in Breast Cancer Metastasis*
**作者**：Smith J, et al.
**摘要**：本研究利用CD49c抗体阻断整合素α3β1的功能，发现其显著抑制乳腺癌细胞的迁移和侵袭能力，表明α3β1在肿瘤转移中的关键作用。
2. **标题**：*CD49c as a Biomarker in Renal Fibrosis*
**作者**：Zhang L, et al.
**摘要**：通过CD49c抗体的免疫组化分析，发现慢性肾病患者肾组织中α3表达上调，并与纤维化程度正相关，提示其作为治疗靶点的潜力。
3. **标题**：*CD49c Antibody-Based Isolation of Mesenchymal Stem Cells*
**作者**：Lee H, et al.
**摘要**：开发了一种基于CD49c抗体的流式分选策略，成功分离出高增殖能力的间充质干细胞，证实CD49c是干细胞的表面标记物。
4. **标题**：*Integrin α3β1 in Cutaneous Wound Healing*
**作者**：Brown K, et al.
**摘要**：在小鼠模型中使用CD49c抗体阻断α3β1.发现表皮再生延迟，表明该整合素通过调控细胞-基质互作促进伤口愈合。
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**建议**：如需真实文献，可通过PubMed或Google Scholar检索关键词“CD49c antibody”、“integrin alpha3”或“ITGA3”，筛选涉及抗体应用(如功能研究、诊断或治疗)的研究。
CD49c antibody targets the CD49c antigen, a subunit of integrin α3 (ITGA3), which pairs with the β1 subunit (ITGB1) to form the heterodimeric receptor α3β1 integrin. Integrins are transmembrane adhesion molecules critical for cell-extracellular matrix (ECM) interactions, mediating processes like cell adhesion, migration, and signaling. The α3β1 integrin specifically binds to ECM components such as laminin, collagen, and fibronectin, playing roles in tissue morphogenesis, wound healing, and cancer progression.
CD49c antibodies are widely used in research to study α3β1 integrin's function in physiological and pathological contexts. In cancer, α3β1 is implicated in tumor invasion, metastasis, and resistance to therapy, with overexpression observed in carcinomas of the breast, lung, and pancreas. Conversely, it also regulates epithelial cell polarity and suppresses aggressive phenotypes in certain contexts, highlighting its dual roles. In developmental biology, α3β1 is essential for kidney and lung organogenesis. CD49c antibodies enable detection of integrin expression via flow cytometry, immunohistochemistry, or Western blot, aiding mechanistic studies.
Therapeutic potential is explored in fibrosis and autoimmune diseases, where aberrant α3β1 activity contributes to pathological ECM remodeling. CD49c antibodies may serve as biomarkers or therapeutic agents, though clinical applications remain investigational. Overall, CD49c antibodies are vital tools for unraveling integrin-mediated cellular processes and their implications in disease.
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