| WB | 1/500 - 1/2000 | Human,Mouse,Monkey |
| IF | 咨询技术 | Human,Mouse,Monkey |
| IHC | 咨询技术 | Human,Mouse,Monkey |
| ICC | 1/200 - 1/1000 | Human,Mouse,Monkey |
| FCM | 咨询技术 | Human,Mouse,Monkey |
| Elisa | 1/10000 | Human,Mouse,Monkey |
| Aliases | TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; DXS707; MCOPS1 |
| Entrez GeneID | 8260 |
| clone | 3G3E9 |
| WB Predicted band size | 26.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey |
| Immunogen | Purified recombinant fragment of human NAA10 (AA: 111-235) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于NAA10抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*NAA10 regulates cell cycle progression via acetylating histones H4K5 and H4K12*
**作者**：Lee, K. et al.
**摘要**：该研究使用NAA10特异性抗体进行染色质免疫沉淀(ChIP)和Western blot分析，发现NAA10通过乙酰化组蛋白H4K5和H4K12调控细胞周期进程，影响肿瘤细胞的增殖能力。
2. **文献名称**：*Overexpression of NAA10 correlates with poor prognosis in colorectal cancer*
**作者**：Wang, Y. et al.
**摘要**：通过免疫组化(IHC)结合NAA10抗体对结直肠癌组织样本分析，发现NAA10高表达与患者预后不良显著相关，提示其作为潜在肿瘤标志物的可能性。
3. **文献名称**：*NAA10 is essential for embryonic development and protein N-terminal acetylation in mice*
**作者**：Liu, X. et al.
**摘要**：利用NAA10抗体在小鼠模型中进行免疫荧光定位和功能研究，证明NAA10缺失导致胚胎致死，并破坏NatA复合体介导的蛋白N端乙酰化，影响多种细胞信号通路。
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如需具体文献来源或更详细内容，建议通过PubMed或Google Scholar检索标题或作者进一步查阅。
The NAA10 antibody is a crucial tool for studying the N-terminal acetyltransferase A (NatA) complex, which plays a pivotal role in co-translational protein modification. NAA10. also known as ARD1. is the catalytic subunit of NatA and mediates the acetylation of approximately 40% of human proteins, influencing protein stability, localization, and interactions. This enzyme is evolutionarily conserved and ubiquitously expressed, underscoring its fundamental role in cellular processes such as cell cycle regulation, apoptosis, and metabolism.
NAA10 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and post-translational modifications. Dysregulation of NAA10 has been implicated in various diseases, including cancers (e.g., breast, liver, and colorectal tumors), where it may act as either an oncogene or tumor suppressor depending on context. Its dual role in cancer progression remains an active research area, with studies suggesting links to hypoxia response, angiogenesis, and metastasis.
Additionally, NAA10 mutations are associated with developmental disorders such as Ogden syndrome, characterized by cardiac arrhythmias and growth delays. Researchers utilize NAA10 antibodies to explore its pathological mechanisms and therapeutic potential. However, challenges persist in distinguishing NAA10 isoforms and differentiating its acetyltransferase activity from non-catalytic functions. Validated antibodies are essential for clarifying these complexities and advancing precision medicine approaches targeting protein acetylation pathways.
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