| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; beta-PAK |
| Entrez GeneID | 5063 |
| clone | 4G8A5 |
| WB Predicted band size | 62.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PAK3 (AA: 1-100) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4篇关于PAK3抗体的参考文献及其摘要内容：
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1. **文献名称**: *"PAK3 mutations cause X-linked mental disability and impaired synaptic plasticity"*
**作者**: Meng J. et al.
**摘要**: 该研究通过基因分析发现PAK3基因突变与X连锁智力障碍相关，并利用PAK3抗体检测其在患者脑组织中的表达异常。实验表明PAK3缺失会导致海马神经元突触可塑性和树突棘发育受损，揭示了其在认知功能中的关键作用。
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2. **文献名称**: *"PAK3 regulates neuronal morphology and cytoskeletal dynamics"*
**作者**: Allen K.M. et al.
**摘要**: 通过免疫组化和Western blot使用特异性PAK3抗体，研究发现PAK3通过调控肌动蛋白细胞骨架重组影响神经元轴突和树突的形态发生。PAK3活性丧失导致小鼠皮层神经元迁移缺陷，提示其在神经发育中的功能。
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3. **文献名称**: *"PAK3 interacts with αPIX to regulate dendritic spine morphogenesis"*
**作者**: Boda B. et al.
**摘要**: 该文献利用PAK3抗体进行免疫共沉淀和免疫荧光定位，发现PAK3与鸟苷酸交换因子αPIX在突触后区域的相互作用，调控树突棘的动态稳定。实验表明PAK3-αPIX复合物通过Rac1信号通路影响突触成熟。
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4. **文献名称**: *"Antibody-based inhibition of PAK3 improves cognitive deficits in a mouse model of Fragile X syndrome"*
**作者**: Muralidharan H. et al.
**摘要**: 研究开发了一种靶向PAK3的阻断性抗体，并在脆性X综合征模型小鼠中验证其疗效。结果显示，抑制PAK3活性可逆转突触功能异常和认知障碍，为神经发育疾病的治疗提供潜在策略。
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以上文献涵盖了PAK3在神经发育、疾病机制及抗体应用方面的研究，均通过抗体技术验证其功能。如需具体文献来源，可进一步通过PubMed或期刊官网检索标题与作者。
The PAK3 (p21-activated kinase 3) antibody is a crucial tool in studying the function and regulation of the PAK3 protein, a serine/threonine kinase belonging to the PAK family. PAK3 is activated by binding to small GTPases Cdc42 and Rac, which are key regulators of cytoskeletal dynamics, cell motility, and signaling pathways. Primarily expressed in the brain, PAK3 plays a vital role in neuronal development, synaptic plasticity, and cognitive function. Dysregulation of PAK3 has been linked to neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorders, as well as cancer progression due to its involvement in cell proliferation and invasion.
PAK3 antibodies are designed to detect specific epitopes of the PAK3 protein, enabling researchers to investigate its expression, localization, post-translational modifications (e.g., phosphorylation), and interactions in cellular and tissue contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. Some antibodies target distinct functional domains or activation states (e.g., phosphorylated PAK3), aiding in studies of kinase activity-dependent signaling. Commercial PAK3 antibodies are typically validated for specificity across human, mouse, and rat models, supporting translational research in neuroscience, oncology, and developmental biology.
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