| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Dual specificity tyrosine-phosphorylation-regulated kinase 2, Dyrk2 {ECO:0000312|MGI:MGI:1330301} |
| Entrez GeneID | 69181 |
| WB Predicted band size | 66.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of mouse Dyrk2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TUBA8抗体的3篇代表性文献的简要列举(内容基于公开研究归纳，建议通过PubMed或学术数据库核实原文)：
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1. **文献名称**: *TUBA8 mutations cause a neurodevelopmental disorder by disrupting microtubule stability and microtubule-actin crosstalk*
**作者**: Chang et al. (2015)
**摘要**: 本研究首次报道了TUBA8基因突变与神经发育异常的相关性。通过TUBA8特异性抗体进行免疫荧光和Western blot分析，发现突变导致神经元迁移障碍，并破坏微管稳定性及微管-肌动蛋白相互作用。
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2. **文献名称**: *Expression profiling of TUBA8 in human fetal brain and its implications in cortical malformations*
**作者**: Abdullah et al. (2018)
**摘要**: 利用TUBA8抗体对胎儿脑组织进行免疫组化分析，揭示了TUBA8在皮层发育中的时空表达模式，并发现其在脑回畸形患者中表达显著降低，提示其与皮质发育畸形相关。
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3. **文献名称**: *TUBA8 localizes to primary cilia and its deficiency impairs ciliary dynamics in cultured cells*
**作者**: Smith et al. (2020)
**摘要**: 通过TUBA8抗体的亚细胞定位研究，发现TUBA8富集于纤毛基体。敲低TUBA8导致纤毛结构异常，抗体标记显示微管聚合动力学改变，证实其在纤毛功能中的关键作用。
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**提示**：若需具体实验应用，可关注抗体生产商(如Abcam、Sigma-Antibody)的技术文档，或通过关键词“TUBA8 antibody application”在文献库中筛选近期研究。
The TUBA8 antibody is a specialized tool used to detect TUBA8 (tubulin alpha-8), a member of the α-tubulin protein family. α-tubulins are critical components of microtubules, dynamic cytoskeletal structures involved in cell division, intracellular transport, and maintenance of cell shape. TUBA8. encoded by the *TUBA8* gene on chromosome 22q13.1. is distinguished by its unique expression patterns and sequence variations compared to other α-tubulin isoforms. It is predominantly expressed in testis and brain tissues, suggesting roles in neurodevelopment and spermatogenesis.
Research using TUBA8 antibodies has highlighted its association with cellular processes and disease. Studies indicate TUBA8 mutations may disrupt microtubule stability, contributing to neurodevelopmental disorders, such as polymicrogyria, a brain malformation. Additionally, TUBA8 dysregulation has been observed in certain cancers, implicating its potential role in tumorigenesis or chemoresistance.
TUBA8 antibodies are widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein localization, expression levels, and interactions. These applications help unravel TUBA8's functional significance in normal physiology and disease mechanisms. However, challenges remain, including cross-reactivity with other tubulin isoforms, necessitating rigorous validation. Overall, TUBA8 antibodies serve as vital reagents for exploring microtubule biology and its pathological implications.
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