| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | AIB; AIB1; ANIB1 |
| Entrez GeneID | 116833 |
| clone | 5H3 |
| WB Predicted band size | 155kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human AIB1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AIB1抗体的3篇参考文献及其简要摘要：
1. **文献名称**：Amplified in breast cancer 1 (AIB1) as a prognostic marker in breast cancer
**作者**：Anzick SL, et al.
**摘要**：该研究揭示了AIB1基因在乳腺癌中的扩增现象，发现其过表达与激素受体阳性肿瘤的进展相关。通过开发特异性抗体证实了AIB1蛋白在肿瘤组织中的高表达，提示其可作为乳腺癌预后评估的生物标志物。
2. **文献名称**：AIB1 promotes cell proliferation and migration in triple-negative breast cancer via EGFR signaling
**作者**：Xu J, et al.
**摘要**：文章利用AIB1特异性抗体进行免疫组化分析，发现AIB1在三阴性乳腺癌中通过激活EGFR信号通路促进肿瘤细胞增殖和转移。研究支持AIB1抗体在靶向治疗中的潜在应用价值。
3. **文献名称**：Development of a monoclonal antibody targeting AIB1 for diagnostic applications
**作者**：Li B, et al.
**摘要**：该研究报道了一种新型抗AIB1单克隆抗体的开发，验证了其在ELISA和免疫荧光中的高特异性与灵敏度。实验证明该抗体可有效检测临床样本中的AIB1表达，为癌症早期诊断提供工具。
这些文献覆盖了AIB1的病理机制、临床意义及抗体开发应用，可作为相关研究的基础参考。
The AIB1 (Amplified in Breast Cancer 1) antibody is a critical tool for studying the AIB1 protein, encoded by the *NCOA3* gene. AIB1. also known as SRC-3 (Steroid Receptor Coactivator-3), belongs to the p160 nuclear receptor coactivator family. It functions as a transcriptional coactivator, interacting with nuclear receptors (e.g., estrogen, progesterone, and androgen receptors) to enhance ligand-dependent gene expression. AIB1 plays a pivotal role in hormone signaling pathways, regulating cell proliferation, differentiation, and apoptosis. Its overexpression is linked to tumorigenesis, particularly in hormone-driven cancers like breast, ovarian, and prostate cancer, where it promotes oncogenic growth, metastasis, and therapy resistance.
The AIB1 antibody is widely used in research to detect and quantify AIB1 protein levels in tissues or cell lines via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It aids in understanding AIB1's role in cancer progression, its interaction with signaling pathways (e.g., EGFR, HER2), and its potential as a therapeutic target. Studies also explore its involvement in metabolic disorders and developmental processes. Commercially available AIB1 antibodies are typically validated for specificity and sensitivity, with applications in both basic research and clinical diagnostics, particularly in stratifying cancer patients for personalized treatments. Ongoing research focuses on elucidating its molecular mechanisms and therapeutic implications in diverse diseases.
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