Mouse Monoclonal CEBPB Antibody

The CEBPB (CCAAT/enhancer-binding protein beta) antibody is a key tool for studying the role of the C/EBPβ transcription factor in cellular processes. C/EBPβ, encoded by the CEBPB gene, regulates gene expression involved in immune response, inflammation, adipogenesis, and cellular differentiation. It is activated by stress signals, cytokines, and hormonal cues, and interacts with other transcription factors to modulate target genes. CEBPB antibodies are widely used in research to detect protein expression levels, subcellular localization, and interactions via techniques like Western blotting (WB), chromatin immunoprecipitation (ChIP), and immunofluorescence/immunohistochemistry (IF/IHC). These antibodies help elucidate C/EBPβ's role in diseases such as cancer, metabolic disorders, and chronic inflammation. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple isoforms (e.g., LAP1. LAP2. LIP). Validated antibodies are critical for studies exploring C/EBPβ's dual roles as an oncogene or tumor suppressor, depending on cellular context. Researchers also use them to investigate post-translational modifications (e.g., phosphorylation) affecting C/EBPβ activity. Proper controls, including knockout cell lines, are essential to confirm antibody specificity in experimental setups.