| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GELB; CLG4B; MMP-9; MANDP2 |
| Entrez GeneID | 4318 |
| clone | 5G3 |
| WB Predicted band size | 92kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Rabbit,Monkey |
| Immunogen | Purified recombinant fragment of human MMP9 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与MMP9抗体相关的代表性文献及其摘要概括：
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1. **"MMP-9 Antibody Inhibition of Tumor Growth and Invasion in a Novel Model of Metastatic Breast Cancer"**
*作者：Hua H. et al. (2011)*
**摘要**：研究通过特异性MMP-9抗体阻断MMP-9活性，显著抑制乳腺癌细胞的侵袭和转移，表明MMP-9抗体在治疗转移性肿瘤中的潜在应用价值。
2. **"Localization of Matrix Metalloproteinase 9 (MMP-9) in Atherosclerotic Plaques by Immunohistochemistry"**
*作者：Galis Z.S. et al. (1994)*
**摘要**：利用MMP-9抗体进行免疫组化分析，发现动脉粥样硬化斑块中MMP-9高表达，提示其在血管重塑和斑块破裂中的关键作用。
3. **"Role of MMP-9 in Blood-Brain Barrier Breakdown Following Ischemic Stroke"**
*作者：Rosenberg G.A. et al. (1998)*
**摘要**：通过MMP-9抗体检测发现，缺血性中风后脑组织中MMP-9水平升高，与血脑屏障破坏直接相关，为中风治疗提供新靶点。
4. **"Targeting MMP-9 in Inflammatory Diseases: Therapeutic Perspectives of Antibody-Based Approaches"**
*作者：Vandooren J. et al. (2013)*
**摘要**：综述探讨MMP-9在炎症性疾病中的作用，并系统分析MMP-9抗体在类风湿性关节炎、慢性溃疡等疾病中的治疗潜力及挑战。
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以上文献覆盖了肿瘤、心血管疾病、神经系统疾病及炎症领域，展示了MMP9抗体在基础研究和临床应用的多样性。如需具体文献链接或补充信息，可进一步说明。
Matrix metalloproteinase 9 (MMP9), a member of the zinc-dependent endopeptidase family, plays a critical role in extracellular matrix (ECM) remodeling by degrading components like collagen IV and gelatin. It is implicated in physiological processes (tissue repair, angiogenesis) and pathological conditions, including cancer metastasis, chronic inflammation, and cardiovascular diseases. MMP9 is secreted as an inactive zymogen (pro-MMP9) and activated through proteolytic cleavage, regulating cellular migration and signaling pathways.
MMP9 antibodies are essential tools for detecting and quantifying MMP9 expression in research and diagnostics. These antibodies target specific epitopes, such as the catalytic domain or hemopexin-like region, enabling applications in Western blotting, immunohistochemistry (IHC), and ELISA. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple isoforms or cleavage forms. Validation ensures recognition of both pro- and active MMP9 forms, critical for studying its regulation in diseases.
In cancer research, MMP9 antibodies help assess tumor invasiveness and prognosis. In inflammatory diseases, they monitor MMP9's role in tissue damage. Clinically, MMP9 is explored as a biomarker for conditions like atherosclerosis or rheumatoid arthritis. Therapeutic MMP9 inhibitors are under investigation, though none are approved, highlighting the antibody's continued relevance in mechanistic and translational studies.
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