关键信息
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基因名
TGFBR1/ALK-5
- 应用
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别名
(TGFR-1)(Activin A receptor type II-like protein kinase of 53kD)(Activin receptor-like kinase 5)(ALK-5)(ALK5)(Serine/threonine-protein kinase receptor R4)(SKR4)(TGF-beta type I receptor)(Transforming growth factor-beta receptor type I)(TGF-beta receptor type I)(TbetaR-I)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36897
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表达区间
34-126aa
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分子量
17.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TGFBR1 (Transforming Growth Factor Beta Receptor 1) and ALK-5 (Activin Like Kinase 5) are critical components of the TGF-β signaling pathway, which plays a vital role in numerous cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of this pathway is implicated in various diseases, including fibrosis, cancer, and cardiovascular disorders. The study of TGFBR1/ALK-5 recombinant proteins aims to elucidate the molecular mechanisms of TGF-β signaling and its downstream effects. Researchers are particularly interested in the receptor's structure, function, and interactions with ligands, as well as how mutations or aberrant expression may contribute to pathological conditions. Utilizing recombinant protein technology enables the production of these receptors in controlled laboratory settings, facilitating functional assays, structural studies, and drug discovery efforts. By understanding the exact role of TGFBR1/ALK-5 in cellular processes, scientists hope to identify potential therapeutic targets for diseases associated with TGF-β signaling dysregulation, ultimately leading to the development of innovative treatments that could ameliorate or even reverse the effects of these diseases.
