| WB | 1/500 - 1/2000 | Human,Monkey |
| IF | 咨询技术 | Human,Monkey |
| IHC | 咨询技术 | Human,Monkey |
| ICC | 技术咨询 | Human,Monkey |
| FCM | 1/200 - 1/400 | Human,Monkey |
| Elisa | 1/10000 | Human,Monkey |
| Aliases | RIG; REIC |
| Entrez GeneID | 27122 |
| clone | 4G7 |
| WB Predicted band size | 38kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Monkey |
| Immunogen | Purified recombinant fragment of human DKK3 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
+ +
以下是关于DKK3抗体的3篇参考文献示例(文献信息为模拟内容，仅供格式参考)：
---
1. **文献名称**: *Serum DKK3 as a Potential Biomarker for Diagnosis and Prognosis in Non-Small Cell Lung Cancer*
**作者**: Matsuura Y, et al. (2020)
**摘要**: 研究通过ELISA检测非小细胞肺癌患者血清中DKK3蛋白水平，发现高表达的DKK3与不良预后相关，提示DKK3抗体可作为肺癌诊断和预后的生物标志物。
2. **文献名称**: *Anti-DKK3 Antibody Attenuates Renal Fibrosis by Inhibiting Wnt/β-Catenin Signaling*
**作者**: Yamaguchi H, et al. (2018)
**摘要**: 实验表明，中和DKK3抗体通过阻断Wnt/β-catenin通路减少肾纤维化模型中胶原沉积，证实DKK3抗体在抑制纤维化中的治疗潜力。
3. **文献名称**: *Targeting DKK3 with a Monoclonal Antibody Improves Anti-Tumor Immunity in Solid Tumors*
**作者**: Sato R, et al. (2021)
**摘要**: 开发了一种靶向DKK3的单克隆抗体，发现其可重塑肿瘤微环境，增强T细胞浸润并协同PD-1抑制剂提高抗肿瘤效果，为免疫治疗提供新策略。
---
如需真实文献，建议在PubMed或Google Scholar中搜索关键词“DKK3 antibody therapeutic”或“DKK3 biomarker”获取近期研究。
**Background of DKK3 Antibodies**
DKK3 (Dickkopf-related protein 3) is a secreted glycoprotein belonging to the Dickkopf family, known for its role in modulating Wnt signaling pathways. Unlike other DKK members (e.g., DKK1), DKK3 exhibits context-dependent effects, acting as either a tumor suppressor or promoter depending on the tissue and disease state. It regulates cell differentiation, apoptosis, and tissue homeostasis, particularly in epithelial and endothelial cells.
DKK3 is epigenetically silenced in various cancers (e.g., lung, prostate, and colorectal), contributing to uncontrolled Wnt/β-catenin activation, tumor progression, and metastasis. Conversely, its overexpression is linked to fibrotic disorders (e.g., liver and kidney fibrosis) by promoting extracellular matrix deposition via TGF-β and other profibrotic pathways.
DKK3 antibodies, including both monoclonal and polyclonal variants, are essential tools for research and diagnostics. They enable detection of DKK3 expression in tissues or serum, aiding in cancer prognosis and fibrosis monitoring. Therapeutic applications are under exploration, with antibody-based strategies aiming to either neutralize DKK3 in fibrotic diseases or restore its tumor-suppressive function in cancers.
Overall, DKK3 antibodies hold dual potential as biomarkers and therapeutic agents, bridging gaps in understanding Wnt-related pathologies and advancing targeted therapies.
×
