Mouse Monoclonal CTNNB1 Antibody

The CTNNB1 antibody targets β-catenin, a multifunctional protein encoded by the CTNNB1 gene that plays pivotal roles in both cell-cell adhesion and Wnt signaling. β-catenin interacts with cadherins at the plasma membrane to maintain tissue architecture, while also serving as a transcriptional co-activator in the canonical Wnt pathway. Dysregulation of β-catenin, often due to CTNNB1 mutations or upstream Wnt pathway alterations (e.g., APC/Axin defects), leads to its nuclear accumulation, driving oncogenic gene expression. This molecular aberration is implicated in various cancers, including colorectal, hepatocellular, and endometrial carcinomas. CTNNB1 antibodies are essential tools for detecting β-catenin localization and expression levels in research and diagnostics, using techniques like immunohistochemistry, Western blotting, and immunofluorescence. They help identify abnormal Wnt activation patterns, assess tumor progression, and evaluate therapeutic responses. Specific antibodies may distinguish between different phosphorylation states or mutant forms of β-catenin, providing insights into disease mechanisms. In clinical settings, CTNNB1 antibody staining patterns can aid in cancer subtyping and prognosis prediction. Recent studies also explore its utility in monitoring β-catenin dynamics during stem cell differentiation and tissue regeneration processes.