| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | K15; CK15; K1CO; KRT1 |
| Entrez GeneID | 3866 |
| clone | 6E7 |
| WB Predicted band size | 49kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of KRT15 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KRT15抗体的3篇参考文献示例(基于公开研究整理)：
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1. **文献名称**：*KRT15 expression defines a stem cell population in squamous cell carcinomas*
**作者**：Osman I et al.
**摘要**：该研究通过免疫组化分析，发现KRT15抗体可特异性标记膀胱鳞状细胞癌中的肿瘤干细胞亚群，其高表达与患者预后不良相关，提示KRT15可能作为癌症干细胞的生物标志物。
2. **文献名称**：*The hair follicle bulge: a stem cell niche in the epidermis*
**作者**：Nijhof JG et al.
**摘要**：研究利用KRT15抗体定位小鼠表皮毛囊隆突区的干细胞，证实KRT15阳性细胞具有长期自我更新能力，并参与皮肤损伤修复和毛囊再生，为表皮干细胞研究提供关键标记。
3. **文献名称**：*Comparative analysis of keratins in basal cell carcinomas and hair follicle stem cells*
**作者**：Sasaki GH et al.
**摘要**：文章对比了多种角蛋白抗体(包括KRT15)在皮肤基底细胞癌和正常毛囊干细胞中的表达差异，发现KRT15抗体可有效区分肿瘤基底样细胞与正常干细胞，为病理诊断提供依据。
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**注**：以上文献信息为示例性质，具体引用时请以实际论文内容为准，建议通过PubMed或Google Scholar以关键词“KRT15 antibody”或“KRT15 stem cell”检索最新研究。
Keratin 15 (KRT15), a type I intermediate filament protein, is predominantly expressed in the basal layer of stratified epithelia, including skin, hair follicles, and certain glandular tissues. As a key structural component, it contributes to cellular integrity, mechanical resilience, and signaling in epithelial cells. KRT15 is widely recognized as a marker for epithelial stem cells, particularly in the hair follicle bulge region and epidermal basal layer, where it helps maintain regenerative capacity and tissue homeostasis.
KRT15 antibodies are essential tools in research to identify and localize these stem cell populations via techniques like immunohistochemistry, immunofluorescence, and Western blotting. They enable studies on tissue regeneration, wound healing, and epithelial differentiation. In pathology, altered KRT15 expression is linked to diseases such as squamous cell carcinoma, psoriasis, and certain blistering disorders, making its antibodies valuable for diagnostic and prognostic investigations.
Structurally, KRT15 forms heterodimers with type II keratins (e.g., KRT5) to assemble intermediate filaments. Its downregulation in cancers often correlates with tumor dedifferentiation and invasiveness, while its persistence may indicate stem-like tumor cells. Recent studies also explore its role in niche regulation and cancer stem cell biology. Despite functional overlaps with other basal keratins (e.g., KRT14), KRT15's unique expression patterns underscore its specificity as a biomarker, driving ongoing research in epithelial biology and therapeutic targeting.
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