| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLM; MGC142015 |
| Entrez GeneID | 3912 |
| clone | 2D9G5 |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LAMB1抗体的3篇文献示例(注：文献为模拟示例，实际引用需根据真实研究补充)：
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1. **文献名称**: *LAMB1 Antibody Targets Tumor Microenvironment in Colorectal Cancer*
**作者**: Smith J, et al.
**摘要**: 研究使用LAMB1特异性抗体分析结直肠癌组织中层粘连蛋白β1的表达，发现LAMB1在肿瘤基质中高表达，且与患者预后不良相关。抗体通过免疫组化验证了LAMB1在血管生成和癌细胞侵袭中的作用。
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2. **文献名称**: *Role of LAMB1 in Neural Development: Insights from Antibody-Based Knockdown*
**作者**: Chen L, et al.
**摘要**: 利用LAMB1中和抗体阻断其功能，发现小鼠胚胎神经嵴细胞迁移异常。研究揭示了LAMB1在神经管闭合和细胞外基质信号传导中的关键作用，抗体实验为机制研究提供了工具。
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3. **文献名称**: *LAMB1 Autoantibodies as a Biomarker in Autoimmune Disorders*
**作者**: Garcia R, et al.
**摘要**: 通过ELISA和Western blot检测患者血清，发现LAMB1自身抗体在系统性硬化症中显著升高，提示其可能参与自身免疫反应中细胞基质的破坏，为疾病诊断提供了潜在标志物。
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如需具体文献，建议在PubMed或Google Scholar中搜索关键词“LAMB1 antibody” + 研究领域(如癌症、发育等)。
**Background of LAMB1 Antibody**
The LAMB1 antibody targets laminin beta-1 (LAMB1), a key subunit of laminins—a family of glycoproteins essential for basement membrane structure and function. Laminins, composed of α, β, and γ chains, facilitate cell adhesion, migration, and signaling by interacting with integrins and other receptors. LAMB1 specifically contributes to the assembly of laminin heterotrimers (e.g., laminin-111), critical for tissue development and homeostasis.
Research using LAMB1 antibodies has highlighted its role in diseases, including cancer metastasis, kidney disorders, and tissue fibrosis. In cancer, aberrant LAMB1 expression correlates with tumor progression and invasion. In renal diseases, LAMB1 defects disrupt glomerular basement membrane integrity, contributing to proteinuria.
Commercially available LAMB1 antibodies (monoclonal or polyclonal) are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein localization and expression. They also aid in diagnosing genetic disorders linked to laminin deficiencies.
Recent studies explore LAMB1's therapeutic potential, such as targeting its signaling pathways in fibrosis or cancer. However, challenges remain in understanding isoform-specific functions due to laminin diversity. Overall, LAMB1 antibodies remain vital tools for dissecting basement membrane biology and its implications in health and disease.
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