| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BYK; Brt; Dtk; RSE; Sky; Tif; FLJ16467 |
| Entrez GeneID | 7301 |
| clone | 6D6F10 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of Tyro3 (aa138-321) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
+ +
以下是3篇关于Tyro3抗体的文献摘要示例(文献名称和内容为虚构示例，仅用于演示格式)：
---
1. **文献名称**: "Development of a monoclonal antibody targeting Tyro3 receptor for cancer immunotherapy"
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种高特异性的抗Tyro3单克隆抗体，通过体外实验验证其阻断Tyro3与配体Gas6的结合能力，并证明其在小鼠模型中抑制肿瘤生长和转移的潜力。
---
2. **文献名称**: "Tyro3 expression and signaling in macrophage polarization"
**作者**: Lee J, et al.
**摘要**: 利用抗Tyro3抗体进行免疫组化和流式细胞术分析，发现Tyro3在M2型巨噬细胞中高表达，并通过PI3K/AKT通路调控炎症反应，提示其在免疫微环境中的调控作用。
---
3. **文献名称**: "Structural characterization of Tyro3 extracellular domain using conformation-specific antibodies"
**作者**: Chen X, et al.
**摘要**: 通过X射线晶体学和抗Tyro3抗体表位定位，揭示了Tyro3胞外域在配体结合时的构象变化，为设计靶向Tyro3的抑制剂提供了结构基础。
---
注：以上内容为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“Tyro3 antibody”获取。
The Tyro3 antibody is a research tool designed to target and detect Tyro3. a receptor tyrosine kinase belonging to the TAM family (Tyro3. Axl, MerTK). Tyro3 plays critical roles in cellular processes such as proliferation, survival, and efferocytosis (clearance of apoptotic cells). It is activated by ligands like Gas6 and Protein S, which bind to its extracellular domain, triggering downstream signaling pathways (e.g., PI3K/AKT, MAPK) that regulate immune responses, neurodevelopment, and homeostasis. Dysregulation of Tyro3 has been linked to cancer progression, autoimmune disorders, and neurodegenerative diseases, making it a potential therapeutic target.
Tyro3 antibodies are widely used in immunoassays (e.g., Western blot, immunohistochemistry, flow cytometry) to study its expression, localization, and function in tissues or cell lines. They also aid in exploring Tyro3's role in tumor microenvironment modulation, immune evasion, and therapeutic resistance. Recent studies highlight Tyro3's involvement in viral entry (e.g., Zika, Ebola) and its crosstalk with immune checkpoints like PD-1/PD-L1.
As research advances, Tyro3 antibodies are increasingly valuable for developing targeted therapies, including small-molecule inhibitors or monoclonal antibodies aimed at blocking Tyro3-mediated oncogenic or immunosuppressive pathways. These tools continue to deepen understanding of Tyro3's dual roles in health and disease.
×
