Mouse Monoclonal MAPK10 Antibody

The MAPK10 antibody is a crucial tool for studying the mitogen-activated protein kinase 10 (MAPK10), also known as c-Jun N-terminal kinase 3 (JNK3). This serine/threonine kinase belongs to the MAPK family, which regulates cellular responses to stress, cytokines, and growth factors. Unlike JNK1 and JNK2. JNK3 is primarily expressed in the brain, heart, and testes, and it plays a significant role in neuronal apoptosis, differentiation, and inflammatory pathways. MAPK10 is activated by dual phosphorylation on Thr221 and Tyr223 residues, typically in response to oxidative stress, ischemia, or excitotoxic signals. Antibodies targeting MAPK10 are designed to detect endogenous levels of total JNK3 or its phosphorylated/activated form, enabling researchers to investigate its expression, localization, and activation status in tissues or cell lysates. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of MAPK10 signaling has been implicated in neurodegenerative diseases (e.g., Alzheimer's and Parkinson's), cancer, and cardiovascular disorders, making its specific antibodies valuable for both basic research and therapeutic target validation. Most MAPK10 antibodies are raised in rabbits or mice using synthetic peptides corresponding to conserved regions of human JNK3. with validation including knockout controls to ensure specificity.